The ability to emulate multiplexed neurochemical transmission is an important step toward mimicking complex brain activities. Glutamate and dopamine are neurotransmitters that regulate thinking and impulse signals independently or synergistically. However, emulation of such simultaneous neurotransmission is still challenging. Here we report design and fabrication of synaptic transistor that emulates multiplexed neurochemical transmission of glutamate and dopamine. The device can perform glutamate-induced long-term potentiation, dopamine-induced short-term potentiation, or co-release-induced depression under particular stimulus patterns. More importantly, a balanced ternary system that uses our ambipolar synaptic device backtrack input ‘true’, ‘false’ and ‘unknown’ logic signals; this process is more similar to the information processing in human brains than a traditional binary neural network. This work provides new insight for neuromorphic systems to establish new principles to reproduce the complexity of a mammalian central nervous system from simple basic units.

模拟多路神经化学传递的能力是模仿复杂脑部活动的重要一步。谷氨酸和多巴胺是独立或协同调节思维和冲动信号的神经递质。然而，这种同时神经传递的模拟仍然具有挑战性。在这里，我们报告设计和制造的突触晶体管的仿真和谷氨酸和多巴胺的多重神经化学传递的设计和制造。该设备可以在特定刺激模式下执行谷氨酸诱导的长期增强，多巴胺诱导的短期增强或共释放诱导的抑郁。更重要的是，一个平衡的三元系统使用我们的双极性突触设备回溯输入“真”，“假”和“未知”逻辑信号；这个过程比传统的二进制神经网络更类似于人脑中的信息处理。这项工作为神经形态系统建立新的原理以从简单的基本单元再现哺乳动物中枢神经系统的复杂性提供了新的见解。