Abstract

Medicinal plants are sources of natural antioxidants thanks to their secondary metabolites. Previous studies showed that administration of Erodium glaucophyllum (EG) (Geraniaceae family) was found to alleviate the deleterious effects of obesity-induced damage on liver, heart and kidney. This study, carried out on adult male Wistar rats, evaluates the inhibitory effects of supplementation with E. glaucophyllum extract on obesity. Under our experimental conditions, administration of Erodium aqueous extract decreased the total cholesterol, LDL-cholesterol, and triglycerides levels as well as ASAT, ALAT, LDH, PAL levels and TBARS concentration; and increased the (HDL) with the antioxidant enzymes (SOD, CAT, GPx) in liver, heart and kidney, compared to HFD group. The anti-obesity effects of the Erodium extract in several organs were mainly due to the interaction of these bioactive molecules (polyphenols, flavonoids, and tannin compounds) and the enzyme system which could be determined by phytochemical analysis.

摘要

由于其次级代谢产物，药用植物是天然抗氧化剂的来源。先前的研究表明，服用Erodium glaucophyllum (EG)（天竺葵科）被发现可以减轻肥胖引起的肝脏、心脏和肾脏损伤的有害影响。这项对成年雄性 Wistar 大鼠进行的研究评估了补充E. glaucophyllum的抑制作用对肥胖症的提取物。在我们的实验条件下，服用 Erodium 水提取物可降低总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平以及 ASAT、ALAT、LDH、PAL 水平和 TBARS 浓度；与 HFD 组相比，肝脏、心脏和肾脏中的抗氧化酶（SOD、CAT、GPx）增加了（HDL）。Erodium 提取物在多个器官中的抗肥胖作用主要是由于这些生物活性分子（多酚、类黄酮和单宁化合物）与酶系统的相互作用，这可以通过植物化学分析确定。