Abstract

Context

Excessive fructose consumption causes ectopic lipid storage leading to metabolic disorders and cardiovascular diseases associated with defective substrate utilisation in the heart.

Objective

Examining the preventive impact of low-intensity exercise on alterations related to fructose-rich diet (FRD) on cardiac fatty acid (FA) transport and metabolism.

Materials and methods

Male Wistar rats were divided into control and two groups that received 10% fructose for 9 weeks, one of which was additionally exposed to exercise.

Results

FRD elevated plasma and cardiac TAG, FATP1 in plasma membrane, Lipin 1 in microsomes and HSL mRNA, while mitochondrial CPT1 was decreased. Exercise decreased plasma free FA level, raised CD36 in plasma membrane and FATP1 in lysate, mitochondrial CPT1 and decreased microsomal Lipin 1 in fructose-fed rats.

Conclusions

FRD changed plasma lipids and augmented partitioning of FA to TAG storage in the heart, whereas exercise in FRD rats switched metabolism of FA towards β-oxidation.

中文翻译：

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低强度运动将果糖喂养大鼠的心脏脂肪酸代谢从三酰甘油合成转向β氧化

摘要

语境

过量果糖消耗会导致异位脂质储存，从而导致代谢紊乱和与心脏底物利用缺陷相关的心血管疾病。

客观的

检查低强度运动对富含果糖饮食 (FRD) 对心脏脂肪酸 (FA) 转运和代谢相关变化的预防性影响。

材料和方法

雄性 Wistar 大鼠被分为对照组和两组，分别接受 10% 果糖 9 周，其中一组还进行运动。

结果

FRD 升高血浆和心脏 TAG、质膜中的 FATP1、微粒体中的 Lipin 1 和 HSL mRNA，而线粒体 CPT1 降低。运动降低了果糖喂养大鼠的血浆游离 FA 水平，提高了质膜中的 CD36 和裂解物中的 FATP1、线粒体 CPT1 并降低了微粒体脂质 1。

结论

FRD 改变了血浆脂质，并增加了 FA 在心脏中向 TAG 储存的分配，而 FRD 大鼠的运动则将 FA 的代谢转变为 β-氧化。