Abstract

Objectives

To identify which factors are associated with cognitive frailty (CF), as well as the impact of CF on the incidence of dementia and mortality.

Methods

A systematic review with meta-analysis was carried out using papers that enrolled a total of 75,379 participants and were published up to January 2020.

Results

Of the 558 identified records, 28 studies met the inclusion criteria and were included in the review. The meta-analysis of cross-sectional studies showed that CF has a significant association of having an older age and a history of falls. In longitudinal studies, the analysis showed a significant increase in risk of mortality and dementia for those with CF.

Discussion

This is the first systematic review and meta-analysis on CF, which addressed a wide variety of factors associated with the theme and which pointed out some as a potential target for prevention or management with different interventions or treatments, showing the clinical importance of its identification in the most vulnerable and susceptible groups.

中文翻译：

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社区老年人认知脆弱的系​​统评价和荟萃分析：风险和相关因素

摘要

目标

确定哪些因素与认知衰弱 (CF) 相关，以及 CF 对痴呆症发病率和死亡率的影响。

方法

使用截至 2020 年 1 月发表的共招募了 75,379 名参与者的论文进行了荟萃分析的系统评价。

结果

在确定的 558 条记录中，有 28 项研究符合纳入标准并被纳入评价。横断面研究的荟萃分析表明，CF 与年龄较大和跌倒史有显着关联。在纵向研究中，分析显示 CF 患者的死亡和痴呆风险显着增加。

讨论

这是对 CF 的第一次系统评价和荟萃分析，涉及与主题相关的多种因素，并指出一些作为预防或管理不同干预或治疗的潜在目标，显示其识别的临床重要性在最脆弱和易受影响的群体中。