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Cell‐extracellular matrix interactions in the fluidic phase direct the topology and polarity of self‐organized epithelial structures
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-02-21 , DOI: 10.1111/cpr.13014
Mingxing Ouyang 1, 2 , Jiun‐Yann Yu 2 , Yenyu Chen 2 , Linhong Deng 1 , Chin‐Lin Guo 2
Affiliation  

In vivo, cells are surrounded by extracellular matrix (ECM). To build organs from single cells, it is generally believed that ECM serves as scaffolds to coordinate cell positioning and differentiation. Nevertheless, how cells utilize cell‐ECM interactions for the spatiotemporal coordination to different ECM at the tissue scale is not fully understood.

中文翻译:

流体相中的细胞-细胞外基质相互作用指导了自组织上皮结构的拓扑和极性

在体内,细胞被细胞外基质(ECM)包围。为了从单个细胞构建器官,通常认为ECM作为支架来协调细胞的定位和分化。然而,细胞在组织尺度上如何利用细胞-ECM相互作用与不同的ECM进行时空协调尚不完全清楚。
更新日期:2021-04-02
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