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PAK4 suppresses motor neuron degeneration in hSOD1G93A‐linked amyotrophic lateral sclerosis cell and rat models
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-02-21 , DOI: 10.1111/cpr.13003
Chaohua Cong 1 , Weiwei Liang 1 , Chunting Zhang 1 , Ying Wang 1 , Yueqing Yang 2 , Xudong Wang 1 , Shuyu Wang 1 , Di Huo 1 , Hongyong Wang 1 , Di Wang 1 , Honglin Feng 1
Affiliation  

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons (MN). CREB pathway‐mediated inhibition of apoptosis contributes to neuron protection, and PAK4 activates CREB signalling in diverse cell types. This study aimed to investigate PAK4’s effect and mechanism of action in ALS.

中文翻译:

PAK4抑制hSOD1G93A相关的肌萎缩性侧索硬化细胞和大鼠模型中的运动神经元变性

肌萎缩性侧索硬化症(ALS)是一种致命的神经退行性疾病,其特征在于运动神经元(MN)逐渐丧失。CREB途径介导的凋亡抑制作用有助于神经元保护,PAK4激活多种细胞类型中的CREB信号传导。这项研究旨在调查PAK4在ALS中的作用和作用机制。
更新日期:2021-04-02
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