Superstructured Biomaterials Formed by Exchange Dynamics and Host–Guest Interactions in Supramolecular Polymers,Advanced Science

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Superstructured Biomaterials Formed by Exchange Dynamics and Host–Guest Interactions in Supramolecular Polymers
Advanced Science ( IF 14.3 ) Pub Date : 2021-02-22 , DOI: 10.1002/advs.202004042
Alexandra N Edelbrock _{1,

2} , Tristan D Clemons _{2,

3} , Stacey M Chin ₃ , Joshua J W Roan ₄ , Eric P Bruckner ₄ , Zaida Álvarez _{2,

5} , Jack F Edelbrock _{2,

4,

5} , Kristen S Wek ₄ , Samuel I Stupp _{1,

2,

3,

4,

5}

Affiliation

Dynamic and reversible assembly of molecules is ubiquitous in the hierarchical superstructures of living systems and plays a key role in cellular functions. Recent work from the laboratory reported on the reversible formation of such superstructures in systems of peptide amphiphiles conjugated to oligonucleotides and electrostatically complimentary peptide sequences. Here, a supramolecular system is reported upon where exchange dynamics and host–guest interactions between β‐cyclodextrin and adamantane on peptide amphiphiles lead to superstructure formation. Superstructure formation with bundled nanoribbons generates a mechanically robust hydrogel with a highly porous architecture that can be 3D printed. Functionalization of the porous superstructured material with a biological signal results in a matrix with significant in vitro bioactivity toward neurons that could be used as a supramolecular model to design novel biomaterials.

中文翻译：

超分子聚合物中交换动力学和主客体相互作用形成的超结构生物材料

分子的动态和可逆组装在生命系统的分层上层结构中普遍存在，并且在细胞功能中发挥着关键作用。实验室最近的工作报告了在与寡核苷酸和静电互补肽序列缀合的肽两亲物系统中这种超结构的可逆形成。在此，报道了一种超分子系统，其中肽两亲物上的β-环糊精和金刚烷之间的交换动力学和主客体相互作用导致超结构的形成。利用成束的纳米带形成上层结构，生成机械坚固的水凝胶，具有高度多孔的结构，可进行 3D 打印。具有生物信号的多孔超结构材料的功能化产生了对神经元具有显着体外生物活性的基质，可以用作超分子模型来设计新型生物材料。

更新日期：2021-04-22

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