Insufficient osseointegration, inflammatory response and bacterial infection are responsible for the majority of bone implant failures. Drug-releasing implants subjected to adequate surface modification can concurrently address these challenges to improve the success of implant surgeries. This work investigates the use of Ti-6Al-4V (Ti64) with a dual-scale surface topography as a platform for local drug delivery. Dual-scale topography was obtained combining the inherent microscale roughness of the Ti64 samples manufactured by selective laser melting (SLM) with the nanoscale roughness of TiO₂ nanotubes (TNTs) obtained by subsequent electrochemical anodization at 60 V for 30 min. TNTs were loaded with a solution of penicillin-streptomycin, a common antibiotic, and drug release was tested in vitro. Three biocompatible and biodegradable polymers, i.e. chitosan, poly(ε-caprolactone) and poly(3-hydroxybutyrate), were deposited by spin coating, while preserving the microscale topography of the substrate underneath. The presence of polymer coatings overall modified the drug release pattern, as revealed by fitting of the experimental data with a power-law model. A slight extension in the overall duration of drug release (about 17% for a single layer and 33% for two layers of PCL and PHB) and reduced burst release was observed for all polymer-coated samples compared to uncoated, especially when two layers of coatings were applied.

骨整合不足，炎症反应和细菌感染是造成大部分骨植入失败的原因。经过适当表面修饰的释药植入物可以同时解决这些挑战，从而提高植入物手术的成功率。这项工作研究了具有双尺度表面形貌的Ti-6Al-4V（Ti64）作为局部药物递送平台的用途。通过选择激光熔化（SLM）制造的Ti64样品固有的微观尺度粗糙度与TiO ₂的纳米尺度粗糙度相结合，获得了双尺度形貌通过随后在60 V下进行30分钟的电化学阳极氧化获得的纳米管（TNT）。在TNT上加入一种常见的抗生素青霉素-链霉素溶液，并在体外测试了药物的释放。通过旋涂沉积了三种生物相容和可生物降解的聚合物，即壳聚糖，聚（ε-己内酯）和聚（3-羟基丁酸酯），同时保留了底材的微观形貌。如通过幂律模型拟合实验数据所揭示的，聚合物涂层的存在总体上改变了药物释放模式。与未涂层相比，所有聚合物涂层样品的药物释放总体持续时间略有延长（单层约为17％，两层PCL和PHB约为33％），突释释放减少。涂覆涂料。