Nanoparticles (NPs) have great potential for biological applications as typically they exhibit strongly size-dependent properties. Specifically, the interaction of NPs with phospholipid membranes is significantly relevant to nanomedicine and the related field of nanotoxicology. Therefore, the investigation of interactions of NPs with model membranes is not only fundamentally important but also practically valuable to understand interactions of NPs with more complex cell membranes. Here, we report on the interaction of anionic vesicles of different charge densities and cationic SiO₂ NPs, either covered by a bare surface functionalized with amino moieties (-NH₂) or covered by poly[2-(dimethylamino) ethyl methacrylate]. We studied the kinetics of binding of NPs to the vesicle surface by time-resolved scattering experiments. A key result of the study is that binding is favored in the presence of electrostatic attraction, but the polymer layer decreases the binding rate drastically.

中文翻译：

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带有磷脂膜的相反电荷的硬和软纳米颗粒的吸附动力学

纳米颗粒（NPs）在生物学上具有巨大的潜力，因为它们通常表现出强烈的尺寸依赖性。具体地，NP与磷脂膜的相互作用与纳米医学和纳米毒理学的相关领域显着相关。因此，研究NP与模型膜的相互作用不仅具有根本的重要性，而且对于理解NP与更复杂的细胞膜的相互作用也具有实用价值。在这里，我们报告了不同电荷密度的阴离子囊泡与阳离子SiO ₂ NPs的相互作用，这些囊泡被氨基部分（-NH _2）官能化的裸露表面覆盖）或被聚[2-（二甲基氨基）甲基丙烯酸乙酯]覆盖。我们通过时间分辨散射实验研究了NPs与囊泡表面结合的动力学。该研究的关键结果是在存在静电吸引的情况下有利于结合，但是聚合物层会大大降低结合速率。