Hepatoprotective Glucosyloxybenzyl 2-Hydroxy-2-isobutylsuccinates from Pleione yunnanensis,Journal of Natural Products

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Hepatoprotective Glucosyloxybenzyl 2-Hydroxy-2-isobutylsuccinates from Pleione yunnanensis
Journal of Natural Products ( IF 3.3 ) Pub Date : 2021-02-19 , DOI: 10.1021/acs.jnatprod.0c01117
Shao-Wei Han ₁ , Xiao-Juan Wang _{1,

2} , Bao-Song Cui ₁ , Hua Sun ₁ , Hui Chen ₁ , Daneel Ferreira ₃ , Shuai Li ₁ , Mark T Hamann ₂

Affiliation

Nine new glucosyloxybenzyl 2-hydroxy-2-isobutylsuccinates, pleionosides M–U (1–9), and 12 known compounds (10–21) were isolated from the pseudobulbs of Pleione yunnanensis. Their structures and absolute configurations were established through a combination of HRESIMS and NMR data and supported by physical and chemical methods. Compounds 5, 6, 10, and 15 showed significant in vitro hepatoprotective activity against d-galactosamine (d-GalN)-induced toxicity in HL-7702 cells with increasing cell viability by 27%, 22%, 19%, and 31% compared to the model group (cf. bicyclol, 14%) at 10 μM, respectively. Compounds 4, 9, and 11 exhibited moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with increasing cell viability by 9%, 16%, and 12% compared to the model group (cf. bicyclol, 9%) at 10 μM, respectively.

中文翻译：

云南椴树的保肝葡糖氧基苄基 2-羟基-2-异丁基琥珀酸酯

九个新glucosyloxybenzyl 2-羟基-2- isobutylsuccinates，pleionosides M-U（1 - 9），和12种的已知化合物（10 - 21）获自的假鳞茎分离叶兰滇。它们的结构和绝对构型是通过结合 HRESIMS 和 NMR 数据建立的，并得到物理和化学方法的支持。化合物5、6、10和15对d -半乳糖胺（d-GalN) 诱导的 HL-7702 细胞毒性，与模型组（参见双环醇，14%）相比，10 μM 的细胞活力分别增加了 27%、22%、19% 和 31%。化合物4，9和11显示出适度的保肝活性针对Ñ乙酰基p氨基苯酚（APAP）的HepG2细胞相比，模型组由9％，16％，和12％的增加细胞活力诱导的毒性（参见双环醇，9%) 分别为 10 μM。

更新日期：2021-03-26

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