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Quinolizidine Alkaloids from Cylicomorpha solmsii
Journal of Natural Products ( IF 3.3 ) Pub Date : 2021-02-19 , DOI: 10.1021/acs.jnatprod.0c01261 Isabelle Pouny 1 , Christophe Long 1 , Muriel Batut 1 , Yannick Aussagues 1 , Naubron Jean Valère 2 , Gaston Achoundong 3 , Bruno David 4 , Catherine Lavaud 5 , Georges Massiot 1, 5
Journal of Natural Products ( IF 3.3 ) Pub Date : 2021-02-19 , DOI: 10.1021/acs.jnatprod.0c01261 Isabelle Pouny 1 , Christophe Long 1 , Muriel Batut 1 , Yannick Aussagues 1 , Naubron Jean Valère 2 , Gaston Achoundong 3 , Bruno David 4 , Catherine Lavaud 5 , Georges Massiot 1, 5
Affiliation
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Five new quinolizidine alkaloids were isolated from the leaves of Cylicomorpha solmstii (Urb.) Urb. (Caricaceae) and named cylicomorphins A–E (1–5). They all are ester derivatives of the same basic quinolizidine skeleton bearing hydroxy, methyl, and ethanoic acid substituents. Their structures were mainly established by NMR spectroscopy, and the absolute configuration is proposed on the basis of VCD data and Mosher ester derivatization. Compound 5 displayed cytotoxicity in the 10 μM range against an HCT-116 cell line.
中文翻译：
来自Cylicomorpha solmsii 的喹诺利西啶生物碱
从Cylicomorpha solmstii (Urb.) Urb的叶子中分离出五种新的喹诺利西啶生物碱。（番木瓜），并命名为cylicomorphins A-E（1 - 5）。它们都是带有羟基、甲基和乙酸取代基的相同基本喹唑啉骨架的酯衍生物。它们的结构主要通过核磁共振光谱确定，绝对构型是根据VCD数据和Mosher酯衍生提出的。化合物5在 10 μM 范围内对 HCT-116 细胞系显示出细胞毒性。
更新日期：2021-04-23
中文翻译：
来自Cylicomorpha solmsii 的喹诺利西啶生物碱
从Cylicomorpha solmstii (Urb.) Urb的叶子中分离出五种新的喹诺利西啶生物碱。（番木瓜），并命名为cylicomorphins A-E（1 - 5）。它们都是带有羟基、甲基和乙酸取代基的相同基本喹唑啉骨架的酯衍生物。它们的结构主要通过核磁共振光谱确定，绝对构型是根据VCD数据和Mosher酯衍生提出的。化合物5在 10 μM 范围内对 HCT-116 细胞系显示出细胞毒性。
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