Galleria mellonella has risen to fame as an invertebrate model organism given its ethical advantages, low maintenance costs, rapid reproduction time, short life cycle, high number of progeny, tolerance for human body temperatures, innate immune system and similarities to mammalian host models. It is increasingly being utilised to evaluate in vivo toxicity and efficacy of chemical compounds and antimicrobials, modelling microbial (bacterial, fungal, viral) pathogenicity and assessing host-pathogen interaction during infection. During this molecular age of genomic, transcriptomic, proteomic, and genetic manipulation approaches, our understanding of microbial pathogenicity and host-pathogen interactions has deepened from high-throughput molecular studies performed in G. mellonella. In this review, we describe the use of G. mellonella in a broad range of studies involving omics, drug resistance, functional analysis and host-microbial community relationships. The future of G. mellonella in the molecular age is bright, with a multitude of new approaches and uses for this model from clinical to biotechnological on the horizon.

中文翻译：

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微生物学的下一个顶级模型：分子时代的 Galleria

Galleria mellonella 因其伦理优势、维护成本低、繁殖时间快、生命周期短、后代数量多、对人体温度的耐受性、先天免疫系统以及与哺乳动物宿主模型的相似性而作为无脊椎动物模式生物而声名鹊起。它越来越多地用于评估化合物和抗微生物剂的体内毒性和功效，模拟微生物（细菌、真菌、病毒）的致病性以及评估感染期间的宿主-病原体相互作用。在这个基因组、转录组、蛋白质组和遗传操作方法的分子时代，我们对微生物致病性和宿主-病原体相互作用的理解从在 G. mellonella 中进行的高通量分子研究中得到了加深。在这篇评论中，我们描述了 G 的使用。在涉及组学、耐药性、功能分析和宿主-微生物群落关系的广泛研究中。G. mellonella 在分子时代的未来是光明的，该模型从临床到生物技术的大量新方法和用途即将出现。