Abstract

A series of 6-acetyl-2,4-diaryl-2,3,4,5-tetrahydro-1,2,4-triazines (2a–2f) was synthesized by double Mannich reaction of the hydrazone 1a or 1b with formaldehyde and the appropriate amine. A similar reaction of 1a with the appropriate diamine afforded the bis(tetrahydro-triazines) 3a–b, and 4a–b. Whereas, the 6-cinnamoyl derivatives 5a-c were obtained by the reaction of 2a with the appropriate aldehyde. The hydrazone 7, derived from 2a, was treated with the appropriate aldehyde or ketone to afford the mixed azines 8–12 and 13–16. The biological activity, antibacterial, antifungal and antioxidants of the most newly synthesized compounds of these derivatives were screened. Compounds 2b, 3a and 7 revealed the best results against all screened biological activity

摘要

通过1 1a或1b与甲醛的双重Mannich反应合成了一系列6-乙酰基2,4-二芳基2,3,4,5-四氢--1,2,4-三嗪（2a-2f）。适当的胺。1a与适当的二胺类似的反应得到双（四氢三嗪）3a–b和4a–b。而6-肉桂酰基衍生物5a - c是通过2a与适当的醛反应获得的。用适当的醛或酮处理衍生自2a的hydr 7，得到混合的嗪8–12和13–16。筛选了这些衍生物的最新合成化合物的生物活性，抗菌，抗真菌和抗氧化剂。化合物2b，3a和7揭示了对抗所有筛选的生物活性的最佳结果