Abstract

A mild, convenient, eco-friendly, general and practical approach has been developed for the synthesis of a series of structurally diverse quinoxaline derivatives via the condensation reactions of various 1,2-diaminobenzene derivatives and 1,2-dicarbonyls such as phenanthrene-9,10-dione, acenaphthylene-1,2-dione or benzil using a catalytic amount of camphor sulfonic acid as an efficient, commercially available, low cost, organo-catalyst in aqueous ethanol at room temperature. Under the same optimized conditions we were also able to synthesis dibenzo[f,h]pyrido[2,3-b]quinoxaline as well as 10-bromoacenaphtho[1,2-b]pyrido[2,3-e]pyrazine from the reactions of pyridine-2,3-diamines and phenanthrene-9,10-dione or acenaphthylene-1,2-dione respectively.

摘要

通过各种1,2-二氨基苯衍生物和1,2-二羰基化合物（如菲-9）的缩合反应，已开发出一种温和，方便，环保，通用的实用方法，用于合成一系列结构多样的喹喔啉衍生物。在室温下，使用催化量的樟脑磺酸作为高效，可商购，低成本的有机催化剂，在乙醇水溶液中制备10-二酮，-1,2-二酮或苯甲腈。在相同的优化条件下，我们还能够合成二苯并[ f，h ]吡啶并[2,3- b ]喹喔啉和10-溴ac [1,2- b ]吡啶并[2,3- e吡啶-2,3-二胺与菲-9,10-二酮或-1,2-二酮的反应中得到]吡嗪。