Spent coffee grounds, a valuable source of phenolic compounds, are considered beneficial for human health because of their antioxidative properties. The liquid extract containing phenolic compounds (such as chlorogenic and gallic acids) can be obtained via extraction using environmentally friendly organic solvent. The separation of chlorogenic and gallic acids from the liquid extract was carried out using isocratic chromatography technique in a three‐zone simulated moving bed (SMB). However, due to the low selectivity of separation, the productivity of three‐zone SMB was sacrificed to meet the purity criteria. Hence this work aimed to enhance the productivity of three‐zone SMB for the separation of chlorogenic and gallic acids via model simulation using partial feed operation and to improve the concentration of extract and raffinate products using partial collection strategy.

中文翻译：

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使用三区域模拟移动床工艺（具有部分进料和部分收集策略），增强了从废咖啡渣中提取的绿原酸和没食子酸的分离

用过的咖啡渣是酚类化合物的重要来源，由于其抗氧化性能，被认为对人体健康有益。含有酚类化合物（例如绿原酸和没食子酸）的液体提取物可以通过使用环境友好的有机溶剂进行提取而获得。使用等度色谱技术在三区模拟移动床（SMB）中从液体提取物中分离绿原酸和没食子酸。但是，由于分离的选择性低，因此牺牲了三区SMB的产率以满足纯度标准。