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Stem cell-based therapies for cardiac diseases: The critical role of angiogenic exosomes
Biofactors ( IF 5.0 ) Pub Date : 2021-02-19 , DOI: 10.1002/biof.1717
Sara Ghodrat 1 , Seyed Javad Hoseini 2 , Shiva Asadpour 3 , Simin Nazarnezhad 4 , Fariba Alizadeh Eghtedar 4 , Saeid Kargozar 4
Affiliation  

Finding effective treatments for cardiac diseases is among the hottest subjects in medicine; cell-based therapies have brought great promises for managing a broad range of life-threatening heart complications such as myocardial infarction. After clarifying the critical role of angiogenesis in tissue repair and regeneration, various stem/progenitor cell were utilized to accelerate the healing of injured cardiac tissue. Embryonic, fetal, adult, and induced pluripotent stem cells have shown the appropriate proangiogenic potential for tissue repair strategies. The capability of stem cells for differentiating into endothelial lineages was initially introduced as the primary mechanism involved in improving angiogenesis and accelerated heart tissue repair. However, recent studies have demonstrated the leading role of paracrine factors secreted by stem cells in advancing neo-vessel formation. Genetically modified stem cells are also being applied for promoting angiogenesis regarding their ability to considerably overexpress and secrete angiogenic bioactive molecules. Yet, conducting further research seems necessary to precisely identify molecular mechanisms behind the proangiogenic potential of stem cells, including the signaling pathways and regulatory molecules such as microRNAs. In conclusion, stem cells' pivotal roles in promoting angiogenesis and consequent improved cardiac healing and remodeling processes should not be ignored, especially in the case of stem cell-derived extracellular vesicles.

中文翻译:

基于干细胞的心脏病疗法:血管生成外泌体的关键作用

寻找有效治疗心脏病的方法是医学界最热门的课题之一。基于细胞的疗法为管理各种危及生命的心脏并发症(如心肌梗塞)带来了巨大希望。在阐明血管生成在组织修复和再生中的关键作用后,利用各种干/祖细胞来加速受损心脏组织的愈合。胚胎、胎儿、成体和诱导多能干细胞已显示出适合组织修复策略的促血管生成潜力。干细胞分化为内皮谱系的能力最初被认为是参与改善血管生成和加速心脏组织修复的主要机制。然而,最近的研究证明了干细胞分泌的旁分泌因子在促进新血管形成中的主导作用。转基因干细胞也被用于促进血管生成,因为它们具有显着过度表达和分泌血管生成生物活性分子的能力。然而,似乎有必要进行进一步的研究以精确识别干细胞促血管生成潜力背后的分子机制,包括信号通路和调节分子,如 microRNA。总之,干细胞在促进血管生成和随后改善的心脏愈合和重塑过程中的关键作用不应被忽视,尤其是在干细胞衍生的细胞外囊泡的情况下。转基因干细胞也被用于促进血管生成,因为它们具有显着过度表达和分泌血管生成生物活性分子的能力。然而,似乎有必要进行进一步的研究以精确识别干细胞促血管生成潜力背后的分子机制,包括信号通路和调节分子,如 microRNA。总之,干细胞在促进血管生成和随后改善的心脏愈合和重塑过程中的关键作用不应被忽视,尤其是在干细胞衍生的细胞外囊泡的情况下。转基因干细胞也被用于促进血管生成,因为它们具有显着过度表达和分泌血管生成生物活性分子的能力。然而,似乎有必要进行进一步的研究以精确识别干细胞促血管生成潜力背后的分子机制,包括信号通路和调节分子,如 microRNA。总之,干细胞在促进血管生成和随后改善的心脏愈合和重塑过程中的关键作用不应被忽视,尤其是在干细胞衍生的细胞外囊泡的情况下。进行进一步的研究似乎有必要精确识别干细胞促血管生成潜力背后的分子机制,包括信号通路和调节分子,如 microRNA。总之,干细胞在促进血管生成和随后改善的心脏愈合和重塑过程中的关键作用不应被忽视,尤其是在干细胞衍生的细胞外囊泡的情况下。进行进一步的研究似乎有必要精确识别干细胞促血管生成潜力背后的分子机制,包括信号通路和调节分子,如 microRNA。总之,干细胞在促进血管生成和随后改善的心脏愈合和重塑过程中的关键作用不应被忽视,尤其是在干细胞衍生的细胞外囊泡的情况下。
更新日期:2021-02-19
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