Soil cadmium (Cd) causes toxicity and oxidative stress, alters biochemical processes and root knot formation in rice. Irrigation of exogenous peroxidase (POX) together with its co-substrate H₂O₂ (POX_Rice + H₂O₂), is likely to have protective effect upon the biochemical and nodular changes in rice grown in Cd-rich soil. Exposure to Cd concentration of 1.00 mg/L increased oxidative stress, loss of cell viability, electrolyte leakage and root knot formation, whereas it significantly lowered the chlorophyll level and rhizobium growth in rice. Irrigation of exogenous POX_Rice + H₂O₂ to Cd-stressed rice seedlings reversed the Cd-induced alterations in rice to levels similar in control (non-stressed) seedlings. Results provided strong evidence of exogenous POX_Rice + H₂O₂-mediated reversal and restoration of physiological and biochemical processes as well as increased resistance of rice seedlings to root knot formation. Irrigation with POX_Rice + H₂O₂ appeared to contribute towards bringing normoxic conditions in the otherwise hypoxic soil environment by enhancing the O₂ in pot-experiments due to reduced Cd uptake, enhanced mineral homeostasis of essential elements viz. P, Fe, Mo, Mg and Mn for maintenance of root architecture damaged by lipid peroxidation and reduction in oxidative stress by reducing Cd-induced reactive oxygen species generation. Therefore, the mitigation of Cd-toxicity in rice through this novel approach appeared to be a promising mode to limit Cd-uptake, modulate protective and tolerance mechanisms for sustainable rice yield in Cd-contaminated rice-croplands and prevent nematode attack in rice, however, more detailed studies are needed prior to large scale applications.

土壤镉（Cd）会导致毒性和氧化应激，改变水稻的生化过程和根结形成。灌溉外源过氧化物酶（POX）及其共底物H ₂ O ₂（POX_水稻 +  H ₂ O ₂）可能对富含Cd的土壤中水稻的生化和结节性变化具有保护作用。Cd浓度为1.00  mg / L会增加氧化应激，细胞活力丧失，电解质渗漏和根结形成，而显着降低水稻的叶绿素水平和根瘤菌生长。外源POX_水稻 +  H ₂ O ₂灌溉镉胁迫的水稻幼苗的逆转将镉诱导的水稻改变逆转至对照（非胁迫）幼苗的水平。结果提供了有力的证据证明外源POX_水稻 +  H ₂ O ₂介导的逆转和生理生化过程的恢复，以及水稻幼苗对根结形成的抗性增强。用POX_水稻 +  H ₂ O ₂灌溉似乎有助于通过增加O _2来在缺氧的土壤环境中带来常氧条件在盆栽试验中，由于减少了Cd的吸收，增强了必需元素的矿物质稳态。P，Fe，Mo，Mg和Mn用于维持因脂质过氧化而受损的根部结构，并通过减少Cd诱导的活性氧物种的产生来降低氧化应激。因此，通过这种新颖的方法减轻水稻中的Cd毒性似乎是一种有前途的模式，它可以限制Cd的吸收，调节受Cd污染的稻田可持续水稻产量的保护和耐受机制，并防止水稻中的线虫侵袭。 ，在大规模应用之前需要进行更详细的研究。