Antibiotics drugs are essential pharmaceutical compounds that play a vital role in the pharmaceutical industry, hospital, and livestock farming. The large scale of pharmaceutical and husbandry effluents are the primary environmental pollutants in water bodies. Even low concentrations of toxic nitroimidazole residues could lead to severe issues for humans and aquatic environments. Simultaneously, electrochemical sensing of cytotoxic antibiotics provides a critical assurance in quality control laboratories, pharmaceutical industries, and in environment pollutant assessment. The electrode surface modification with an excellent electrocatalyst paves the way for the effective determination of these cytotoxic antibiotics. Herein, Noble metal silver incorporated carrom coin structured cobalt oxide (Ag-Co₃O₄ NPs) was synthesized through a simple co-precipitation technique, and its electrocatalytic actives sites were improved via calcination at 600℃. The modified electrodes were implemented in the electrochemical detection of cytotoxic Tinidazole (TNZ). The electrochemical characterization shows low charge transfer resistance (R_ct) and prominent electrochemical active surface area. Due to its unique properties, Ag-Co₃O₄ NPs modified glassy carbon electrode (GCE) exhibits excellent sensitivity, stability, reproducibility, and low detection level up to the Nanomolar scale. Further, it also provides excellent selectivity among other interfering drugs and species. Meanwhile, it paves strategies for the real-time monitoring of TNZ in biological, pharmaceutical, livestock and various wastewater samples which could paves way for effective application in electrochemical sensors.

抗生素药物是必不可少的药物化合物，在制药业，医院和畜牧业中发挥着至关重要的作用。大规模的制药和畜牧业废水是水体中的主要环境污染物。即使低浓度的有毒硝基咪唑残留物也可能导致对人类和水生环境的严重危害。同时，细胞毒性抗生素的电化学检测为质量控制实验室，制药行业和环境污染物评估提供了关键保证。用出色的电催化剂修饰电极表面为有效测定这些细胞毒性抗生素铺平了道路。此处，贵金属银结合的卡罗姆硬币结构的氧化钴（Ag-Co ₃ O通过简单的共沉淀技术合成了_4个NPs，通过在600℃下煅烧可以改善其电催化活性。修饰电极用于细胞毒性替硝唑（TNZ）的电化学检测。电化学表征显示出低的电荷转移电阻（R _ct）和突出的电化学活性表面积。由于其独特的特性，Ag-Co ₃ O ₄NPs修饰的玻碳电极（GCE）表现出出色的灵敏度，稳定性，可重复性，并且检测水平低至纳摩尔级。此外，它在其他干扰药物和物种中也具有出色的选择性。同时，它为生物，制药，牲畜和各种废水样品中TNZ的实时监测奠定了策略，这可能为在电化学传感器中的有效应用奠定了基础。