Endocrine disrupting chemicals (EDCs) include non-persistent exogenous substances such as parabens, bisphenols and phthalates which have been associated with a range of metabolic disorders and disease. It is unclear if exposure remains consistent over time. We investigated change in indicators of EDC exposure between 2009 and 2016 and assessed its consistency between and within individuals over a median follow-up time of 47 months in a sample of Dutch individuals. Of 500 Dutch individuals, two 24 h urine samples were analysed for 5 parabens, 3 bisphenols and 13 metabolites of in total 8 different phthalates. We calculated per-year differences using meta-analysis and assessed temporal correlations between and within individuals using Spearman correlation coefficients, intra-class correlation coefficients (ICC) and kappa-statistics. We found a secular decrease in concentrations of methyl, ethyl, propyl and n-butyl paraben, bisphenol A, and metabolites of di-ethyl phthalate (DEP), di-butyl phthalate (DBP), di-(2-ethyl-hexyl) phthalate (DEHP), and butylbenzyl phthalate (DBzP) which varied from 8 to 96% (ethyl paraben, propyl paraben) between 2009 and 2016. Within-person temporal correlations were highest for parabens (ICC: 0.34 to 0.40) and poorest for bisphenols (ICC: 0.15 to 0.23). For phthalate metabolites, correlations decreased most between time periods (ICC < 48 months: 0.22 to 0.39; ≥48 months: 0.05 to 0.32). When categorizing EDC concentrations, 33–54% of individuals remained in the lowest or highest category and temporal correlations were similar to continuous measurements. Exposure to most EDCs decreased between 2009 and 2016 in a sample of individuals with impaired fasting glucose from the Dutch population. Temporal consistency was generally poor. The inconsistency in disease associations may be influenced by individual-level or temporal variation exhibited by EDCs. Our findings call for the need for repeated measurements of EDCs in observational studies before and during at-risk temporal windows for the disease.

内分泌干​​扰化学品 (EDC) 包括非持久性外源性物质，例如对羟基苯甲酸酯、双酚和邻苯二甲酸酯，这些物质与一系列代谢紊乱和疾病有关。目前尚不清楚暴露是否随着时间的推移保持一致。我们调查了 2009 年至 2016 年期间 EDC 暴露指标的变化，并在荷兰个体样本中评估了其在 47 个月的中位随访时间内在个体之间和个体内部的一致性。在 500 名荷兰人中，对两个 24 小时尿样进行了 5 种对羟基苯甲酸酯、3 种双酚和 8 种不同邻苯二甲酸酯的 13 种代谢物的分析。我们使用荟萃分析计算了每年的差异，并使用 Spearman 相关系数、类内相关系数 (ICC) 和 kappa 统计评估了个体之间和个体内部的时间相关性。我们发现甲基、乙基、丙基和对羟基苯甲酸正丁基酯、双酚 A 以及邻苯二甲酸二乙酯 (DEP)、邻苯二甲酸二丁酯 (DBP)、二-(2-乙基-己基) 的代谢物的浓度长期下降邻苯二甲酸酯 (DEHP) 和邻苯二甲酸丁苄酯 (DBzP) 在 2009 年至 2016 年间从 8% 变化到 96%（对羟基苯甲酸乙酯、对羟基苯甲酸丙酯）。对羟基苯甲酸酯的人体内时间相关性最高（ICC：0.34 至 0.40），双酚的时间相关性最差（ICC：0.15 至 0.23）。对于邻苯二甲酸酯代谢物，时间段之间的相关性下降最多（ICC < 48 个月：0.22 至 0.39；≥48 个月：0.05 至 0.32）。在对 EDC 浓度进行分类时，33-54% 的个体仍处于最低或最高类别，并且时间相关性类似于连续测量。在 2009 年至 2016 年期间，荷兰人群的空腹血糖受损个体样本中大多数 EDC 的暴露量有所减少。时间一致性普遍较差。疾病关联的不一致性可能受到 EDC 表现出的个体水平或时间变化的影响。我们的研究结果要求在该疾病的高危时间窗口之前和期间的观察性研究中重复测量 EDC。