Abstract

Novel multicompartment self-assemblies of triblock copolymer polystyrene–polyisoprene–poly(2-vinylpyridine) (PS-PI-P2VP) for drug delivery are demonstrated. The triblock copolymer assemblies in dilute solutions in a common solvent (tetrahydrofuran) undergo transformations from core-shell-corona micelles to multicompartment micelles by adding P2VP-selective solvent (water). The effects of water content and pH on the assembled structures were systematically investigated. Multicompartment micelles are also obtained by adding a surfactant, 4-biphenylcarboxylic acid, into the solution. Such multicompartment self-assemblies are used as carriers for encapsulation and release of an anticancer drug doxorubicin hydrochloride (DOX). The drug loading content and drug loading efficiency of DOX were evaluated. The DOX release experiments were performed at 37°C under pH 5.5 and pH 7.4. The DOX release rate was improved as pH decreased from pH 7.4 to 5.0, with 45.6% release of DOX in 32 h.

中文翻译：

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用于药物递送的三嵌段共聚物的多隔室自组装体

摘要

展示了三嵌段共聚物聚苯乙烯-聚异戊二烯-聚（2-乙烯基吡啶）（PS-PI-P2VP）的新型多隔室自组装体。在普通溶剂（四氢呋喃）的稀溶液中的三嵌段共聚物组件通过添加P2VP选择性溶剂（水）经历从核-壳-电晕胶束到多室胶束的转变。系统研究了水含量和pH对组装结构的影响。也可以通过向溶液中添加表面活性剂4-联苯甲酸来获得多室胶束。这种多隔室的自组装体被用作载体用于封装和释放抗癌药物盐酸阿霉素（DOX）。评价DOX的载药量和载药效率。DOX释放实验是在37°C，pH 5.5和pH 7.4下进行的。随着pH值从7.4降低到5.0，DOX释放速率得到了提高，在32小时内释放了45.6％的DOX。