Colon cancer is one of the most common causes of death by cancer worldwide. Stem cells have immunosuppressive properties that promote tumor targeting and circumvent obstacles currently in gene therapy. Bone marrow stem cells are believed to have anticancer potential. The transplantation of mesenchymal stem cells (MSCs), a type of bone marrow stem cells, has been considered a potential therapy for patients with solid tumors due to their capability to enhance the immune response; MSC transplantation has received renewed interest in recent years. This study aimed to evaluate the antiapoptotic effects of the MSCs on 1,2-dimethylhydrazine (DMH)-induced inflammation in the rat model of colorectal cancer. The rats were randomly allocated into four groups: control, treated with MSCs, induced by DMH, and induced by DMH and treated with MSCs. The MSCs were intra-rectally injected, and DMH was subcutaneously injected at 20 mg/kg body weight once a week for 15 weeks. The administration of MSCs into rats starting from day 0 of the DMH injection was found to enhance the histopathological picture. The MSC treatment resulted in fewer inflammatory cells than in the DMH group. Therefore, our findings suggest that BMCs have antitumor effects by modulating the cellular redox status and down-regulating the pro-inflammatory genes. Thus, BMCs may provide therapeutic value for colon cancer treatment.

中文翻译：

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间充质干细胞对 1,2-二甲基肼诱导的 Wistar 白化大鼠结肠癌细胞色素-c 释放和炎症的影响。

结肠癌是世界范围内最常见的癌症死亡原因之一。干细胞具有免疫抑制特性，可促进肿瘤靶向并规避目前基因治疗中的障碍。骨髓干细胞被认为具有抗癌潜力。间充质干细胞 (MSCs) 是一种骨髓干细胞，由于其增强免疫反应的能力，被认为是治疗实体瘤患者的潜在疗法。近年来，MSC 移植重新受到关注。本研究旨在评估 MSCs 对 1,2-二甲基肼 (DMH) 诱导的结直肠癌模型炎症的抗细胞凋亡作用。将大鼠随机分为四组：对照组、MSCs治疗组、DMH诱导组、DMH诱导组和MSCs治疗组。MSCs 直肠内注射，DMH 以 20 mg/kg 体重每周一次皮下注射，持续 15 周。发现从 DMH 注射的第 0 天开始向大鼠施用 MSC 可以增强组织病理学图像。MSC 治疗导致的炎症细胞比 DMH 组少。因此，我们的研究结果表明，BMCs 通过调节细胞氧化还原状态和下调促炎基因具有抗肿瘤作用。因此，BMCs 可能为结肠癌治疗提供治疗价值。MSC 治疗导致的炎症细胞比 DMH 组少。因此，我们的研究结果表明，BMCs 通过调节细胞氧化还原状态和下调促炎基因具有抗肿瘤作用。因此，BMCs 可能为结肠癌治疗提供治疗价值。MSC 治疗导致的炎症细胞比 DMH 组少。因此，我们的研究结果表明，BMCs 通过调节细胞氧化还原状态和下调促炎基因具有抗肿瘤作用。因此，BMCs 可能为结肠癌治疗提供治疗价值。