Spontaneous intracerebral hemorrhage (sICH) is one of the deadliest subtypes of stroke, and no treatment is currently available. One of the major risk factors is tobacco use. In this article, we review literature on how tobacco use affects the risk of sICH and also summarize the known effects of tobacco use on outcomes following sICH. Several studies demonstrate that the risk of sICH is higher in current cigarette smokers compared to non-smokers. The literature also establishes that cigarette smoking not only increases the risk of sICH but also increases hematoma growth, results in worse outcomes, and increases the risk of death from sICH. This review also discusses potential mechanisms activated by tobacco use which result in an increase in risk and severity of sICH. Exploring the underlying mechanisms may help alleviate the risk of sICH in tobacco users as well as may help better manage tobacco user sICH patients.

中文翻译：

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烟草使用：脑出血的主要危险因素。

自发性脑出血（sICH）是中风最致命的亚型之一，目前尚无治疗方法。主要危险因素之一是吸烟。在本文中，我们回顾了有关烟草使用如何影响sICH风险的文献，并总结了烟草使用对sICH后结果的已知影响。多项研究表明，与不吸烟者相比，当前吸烟者中sICH的风险更高。文献还确定，吸烟不仅增加了sICH的风险，而且还增加了血肿的生长，导致不良结局，并增加了因sICH死亡的风险。这篇综述还讨论了使用烟草激活的潜在机制，这些机制导致sICH的风险和严重性增加。