In recent years, nosocomial infections and antibiotic resistance are major public health problems. Nanotechnology should open new avenues to treat and prevent diseases. In this research work, iron-doped tin dioxide (Fe-SnO₂) nanoparticles have been synthesized by the chemical co-precipitation method. X-ray diffraction analysis confirms the formation of nanocrystalline SnO₂ single phase with Fe favoring grain growth, the crystallite size increases from 13 up to 29 nm. FT-infrared spectroscopy analysis shows the presence of peaks characteristic of the SnO₂ phase. Ultraviolet-visible spectroscopy analysis indicates Fe doping induces red-shift of SnO₂ bandgap. Morphological observations by scanning electron microscopy reveal randomly arranged irregular-sized compact grains with sponge-like microstructure. Energy dispersive X-ray spectroscopy analysis (EDX) confirms the purity of Fe-doped SnO₂. Bacteria produce siderophores capable of capturing iron, a necessary nutrient. For this reason, SnO₂ has been doped particularly with Fe to facilitate the entry of nanoparticles into the bacterial cell and improve its antibacterial activity. Fe-SnO₂ nanoparticles exhibit significant antimicrobial and anti-biofilm activities against all tested microorganisms; it is found that biofilm eradication of the tested strains is higher than 90%. The fabricated Fe–SnO₂ nanopowders have potential as antiseptics and disinfectants that will eliminate, kill, or inactivate microorganisms usually found on inert surfaces such as soil, walls, medical-surgical equipment, to prevent nosocomial infections in hospitals.

近年来，医院感染和抗生素耐药性是主要的公共卫生问题。纳米技术应开辟治疗和预防疾病的新途径。在这项研究工作中，已通过化学共沉淀法合成了铁掺杂的二氧化锡（Fe-SnO ₂）纳米粒子。X射线衍射分析证实形成了Fe有利于晶粒生长的纳米晶SnO ₂单相，微晶尺寸从13增大到29 nm。FT-红外光谱分析表明存在SnO ₂相特征峰。紫外可见光谱分析表明，Fe掺杂引起SnO ₂的红移带隙。通过扫描电子显微镜的形态学观察揭示了具有海绵状微观结构的无规排列的不规则尺寸的致密晶粒。能量色散X射线光谱分析（EDX）证实了掺Fe的SnO ₂的纯度。细菌产生的铁载体能够捕获铁（一种必要的营养素）。由于这个原因，SnO ₂已经特别地掺杂有Fe，以促进纳米颗粒进入细菌细胞并改善其抗菌活性。Fe-SnO ₂纳米颗粒对所有测试的微生物均表现出显着的抗微生物和抗生物膜活性。发现被测菌株的生物膜根除率高于90％。制备的Fe–SnO ₂ 纳米粉具有作为杀菌剂和消毒剂的潜力，可以消除，杀死或灭活通常在惰性表面（例如土壤，墙壁，医疗手术设备）上发现的微生物，以防止医院中的医院感染。