ObjectiveHere, we provide an experimental test of the relationship between levels of proinflammatory cytokines and present-focused decision-making.MethodsWe examined whether increases in salivary levels of proinflammatory cytokines (interleukin-1β and interleukin-6) engendered by visually priming immunologically-relevant threats (pathogen threat, physical harm) and opportunities (mating) predicted temporal discounting, a key component of present-focused decision-making.ResultsAs hypothesized, results revealed that each experimental manipulation led to a significant rise in both salivary interleukin-1β and interleukin-6. Moreover, post-manipulation levels of each cytokine independently predicted temporal discounting across conditions. These results were not moderated by pre-manipulation levels of either cytokine, nor were they found using the difference between pre- and post-manipulation levels of cytokines as a predictor.ConclusionsTogether, these results suggest that levels of proinflammatory cytokines may play a mechanistic role in the desire for immediately available rewards.

中文翻译：

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实验诱发的炎症预测当前的焦点

目的在这里，我们提供了实验性检验促炎细胞因子水平与当前重点决策之间关系的方法。方法我们检查了视觉引发免疫学相关威胁是否导致唾液促炎细胞因子（白细胞介素-1β和白细胞介素-6）水平升高。 （病原体威胁，人身伤害）和机会（交配）预测时间折现，这是当前研究决策的关键组成部分。结果如所假设的那样，结果表明，每次实验操作均导致唾液白介素1β和白介素- 6。此外，每个细胞因子的操纵后水平独立预测跨条件的时间折现。这些结果并未被任何一种细胞因子的操作前水平所调节，