Approaches in metabolomics for regulatory toxicology applications,Analyst

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Approaches in metabolomics for regulatory toxicology applications
Analyst ( IF 3.6 ) Pub Date : 2021-2-9 , DOI: 10.1039/d0an02212h
Eulalia Olesti _{1,

2,

2,

3,

4} , Víctor González-Ruiz _{1,

2,

2,

3,

4} , Martin F. Wilks _{3,

3,

5,

6,

7} , Julien Boccard _{1,

2,

2,

3,

4} , Serge Rudaz _{1,

2,

2,

3,

4}

Affiliation

Innovative methodological approaches are needed to conduct human health and environmental risk assessments on a growing number of marketed chemicals. Metabolomics is progressively proving its value as an efficient strategy to perform toxicological evaluations of new and existing substances, and it will likely become a key tool to accelerate chemical risk assessments. However, additional guidance with widely accepted and harmonized procedures is needed before metabolomics can be routinely incorporated in decision-making for regulatory purposes. The aim of this review is to provide an overview of metabolomic strategies that have been successfully employed in toxicity assessment as well as the most promising workflows in a regulatory context. First, we provide a general view of the different steps of regulatory toxicology-oriented metabolomics. Emphasis is put on three key elements: robustness of experimental design, choice of analytical platform, and use of adapted data treatment tools. Then, examples in which metabolomics supported regulatory toxicology outputs in different scenarios are reviewed, including chemical grouping, elucidation of mechanisms of toxicity, and determination of points of departure. The overall intention is to provide insights into why and how to plan and conduct metabolomic studies for regulatory toxicology purposes.

中文翻译：

代谢组学方法在调节毒理学中的应用

需要创新的方法来对越来越多的市售化学品进行人类健康和环境风险评估。代谢组学正在逐步证明其作为对新物质和现有物质进行毒理学评估的有效策略的价值，它很可能会成为加速化学风险评估的关键工具。但是，在将代谢组学常规纳入监管目的的决策过程中之前，还需要具有广泛接受和统一程序的其他指导。这篇综述的目的是概述已经成功用于毒性评估的代谢组学策略，以及监管背景下最有前途的工作流程。首先，我们提供了面向监管毒理学的代谢组学的不同步骤的一般视图。重点放在三个关键要素上：实验设计的稳健性，分析平台的选择以及改编的数据处理工具的使用。然后，回顾了在不同情况下代谢组学支持法规毒理学输出的示例，包括化学分组，阐明毒性机制以及确定出发点。总体目的是提供有关为什么以及如何计划和进行代谢组学研究以用于监管毒理学目的的见解。和出发点的确定。总体目的是提供有关为什么以及如何计划和进行代谢组学研究以用于监管毒理学目的的见解。和确定出发点。总体目的是提供有关为什么以及如何计划和进行代谢组学研究以用于监管毒理学目的的见解。

更新日期：2021-02-19

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