To synthesize evidence for prefrontal cortex (PFC), quadriceps, and respiratory muscle oxygenation using near-infrared spectroscopy (NIRS) during cycling in individuals with chronic obstructive pulmonary disease (COPD). A scoping review was performed searching databases (inception-August 2020): Ovid MEDLINE, EMBASE, Cochrane Systematic Reviews, Cochrane Central Register of Controlled Clinical Trials, CINAHL, SPORTDiscus and Pedro. The search focused on COPD, cycling, and NIRS outcomes. 29 studies (541 COPD participants) were included. Compared to healthy individuals (8 studies), COPD patients at lower cycling workloads had more rapid increases in vastus lateralis (VL) deoxygenated hemoglobin (HHb); lower increases in VL total hemoglobin (tHb) and blood flow; and lower muscle tissue saturation (StO₂). Heliox and bronchodilators were associated with smaller and slower increases in VL HHb. Heliox increased VL and intercostal blood flow compared to room air and supplemental oxygen in COPD patients (1 study). PFC oxygenated hemoglobin (O₂Hb) increased in COPD individuals during cycling in 5 of 8 studies. Individuals with COPD and heart failure demonstrated worse VL and PFC NIRS outcomes compared to patients with only COPD—higher or more rapid increase in VL HHb and no change or decrease in PFC O₂Hb. Individuals with COPD present with a mismatch between muscle oxygen delivery and utilization, characterized by more rapid increase in VL HHb, lower muscle O₂Hb and lower muscle StO₂. PFC O₂Hb increases or tends to increase in individuals with COPD during exercise, but this relationship warrants further investigation. NIRS can be used to identify key deoxygenation thresholds during exercise to inform PFC and muscle oxygenation.

使用近红外光谱 (NIRS) 在慢性阻塞性肺病 (COPD) 患者骑自行车期间合成前额叶皮层 (PFC)、股四头肌和呼吸肌氧合的证据。对数据库（2020 年 8 月成立）进行了范围审查：Ovid MEDLINE、EMBASE、Cochrane Systematic Reviews、Cochrane Central Register of Controlled Clinical Trials、CINAHL、SPORTDiscus 和 Pedro。搜索的重点是 COPD、骑自行车和 NIRS 结果。包括 29 项研究（541 名 COPD 参与者）。与健康个体（8 项研究）相比，骑行负荷较低的 COPD 患者股外侧肌 (VL) 脱氧血红蛋白 (HHb) 增加更快；VL 总血红蛋白 (tHb) 和血流量增加较少；和较低的肌肉组织饱和度 (StO ₂）。氦氧混合气和支气管扩张剂与 VL HHb 的较小和较慢的增加有关。与 COPD 患者的室内空气和补充氧气相比，Heliox 增加了 VL 和肋间血流量（1 项研究）。在 8 项研究中的 5 项中，COPD 个体在骑自行车期间PFC 氧合血红蛋白 (O ₂ Hb) 增加。与仅患有 COPD 的患者相比，患有 COPD 和心力衰竭的个体表现出更差的 VL 和 PFC NIRS 结果——VL HHb 更高或更快速地增加，而 PFC O ₂ Hb没有变化或减少。患有 COPD 的个体存在肌肉氧输送和利用之间的不匹配，其特征是 VL HHb 增加更快，肌肉 O ₂ Hb 和肌肉 StO ₂降低。PFC O ₂在运动期间，COPD 患者的 Hb 增加或趋于增加，但这种关系值得进一步调查。NIRS 可用于识别运动期间的关键脱氧阈值，以告知 PFC 和肌肉氧合。