Homochirality is a feature of life, but its origin is still disputed. Recent theories indicate that the origin of homochirality coincided with that of the RNA world, but proteins have not yet been incorporated into the story. Ribosome is considered a living fossil that survived the RNA world and records the oldest interaction between RNA and proteins. Inspired by several ribosome-related findings, we propose a hypothesis as follows: the substrate chirality preference of some primitive peptide synthesis ribozymes can mediate the chirality transmission from RNA to protein. In return, the chiral preference of protective peptide-RNA interaction can bring these ribozymes an evolutionary advantage and facilitate the expansion of enantiomeric excess in peptides. Monte Carlo simulation results show that this system's chemistry model is plausible. This model can be further tested through investigation of the chirality preference for the interactions between d/l-ribose-composed rRNA homologs and l/d-amino acid-composed peptides.

中文翻译：

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蛋白质同手性可能源自 RNA 的原始肽合成

同手性是生命的一个特征，但其起源仍存在争议。最近的理论表明同源手性的起源与 RNA 世界的起源一致，但蛋白质尚未被纳入这个故事。核糖体被认为是在 RNA 世界中幸存下来的活化石，并记录了 RNA 与蛋白质之间最古老的相互作用。受几个核糖体相关发现的启发，我们提出如下假设：一些原始肽合成核酶的底物手性偏好可以介导从 RNA 到蛋白质的手性传递。作为回报，保护性肽-RNA 相互作用的手性偏好可以为这些核酶带来进化优势，并促进肽中对映体过量的扩大。Monte Carlo 模拟结果表明该系统的化学模型是合理的。d/l -核糖组成的 rRNA 同源物和l/d -氨基酸组成的肽。