ABSTRACT

Background: The association between cystatin C (CysC) and atherosclerosis has been shown in numerous studies in hypertensive patients and in various patient groups with high cardiovascular risk. The study examining the association between renal volume and atherosclerosis is very limited. This study aimed to investigate whether there is an association between the presence of atherosclerosis with CysC and renal volume in hypertensive patients.

Methods: 133 hypertensive patients and 80 healthy volunteers were evaluated. CysC level was studied in the blood sample taken from all participants. Carotid intima media thickness (CIMT) and renal volume were measured with ultrasound always by the same radiologist. Laboratory findings, CysC, CIMT, and renal volume measurements of the groups were compared statistically.

Results: There was no significant difference in mean renal volume values between hypertension and control groups. There was no significant correlation between renal volume with albuminuria and proteinuria. CIMT was significantly higher in hypertension group than in control group (p = .003). There was a significant correlation between renal volume and CIMT, which is an indicator of subclinical atherosclerosis (r = 0.213, p = .001). Renal volume was found to be an independent predictor of CIMT when corrected with variables such as age, BMI, serum LDL-cholesterol level, creatinine, CysC, and albumin-to-creatinine ratio.

Conclusion: Ultrasonographic renal volume measurement, which is easy to perform and does not take a long time, can be a useful method for predicting the presence of atherosclerosis in hypertensive patients with GFR >60 ml/min.

摘要

背景：在许多高血压患者和心血管高危患者群体的许多研究中，已证明了胱抑素C（CysC）与动脉粥样硬化之间的关联。研究肾体积与动脉粥样硬化之间关系的研究非常有限。这项研究旨在调查高血压患者中动脉粥样硬化与CysC的存在和肾脏容量之间是否存在关联。

方法：对133名高血压患者和80名健康志愿者进行评估。在所有参与者的血液样本中研究了CysC水平。颈动脉内膜中层厚度（CIMT）和肾脏体积总是由同一位放射科医生进行超声测量。比较两组的实验室检查结果，CysC，CIMT和肾体积测量值。

结果：高血压组和对照组之间的平均肾脏体积值无显着差异。肾脏容量与蛋白尿和蛋白尿之间无显着相关性。高血压组的CIMT显着高于对照组（p = .003）。肾容量和CIMT之间存在显着相关性，这是亚临床动脉粥样硬化的指标（r = 0.213，p = .001）。当使用变量（例如年龄，BMI，血清LDL-胆固醇水平，肌酐，CysC和白蛋白与肌酐之比）进行校正后，发现肾脏体积是CIMT的独立预测指标。

结论：超声肾体积测量操作简便，无需花费很长时间，可作为预测GFR> 60 ml / min的高血压患者是否存在动脉粥样硬化的有用方法。