Direct determination of helix structures involved in the screw‐sense reversal of poly(β‐phenylpropyl l‐aspartate) by synchrotron X‐ray diffraction,Journal of Peptide Science

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Direct determination of helix structures involved in the screw‐sense reversal of poly(β‐phenylpropyl l‐aspartate) by synchrotron X‐ray diffraction
Journal of Peptide Science ( IF 1.8 ) Pub Date : 2021-02-18 , DOI: 10.1002/psc.3311
Yuki Orito ₁ , Hiroyasu Masunaga ₂ , Hidemine Furuya ₁ , Akihiro Abe ₃

Affiliation

The helix‐sense reversal of poly(β‐phenylpropyl l‐aspartate) (3PLA) in the solid state was studied by synchrotron wide‐angle X‐ray diffraction and small‐angle X‐ray scattering. The direct determination of the characteristic helical pitch before and after the transition revealed that the transition takes place reversibly between the two α‐helices having opposite screw‐sense during the heating and cooling cycle. While the hexagonal packing remains unaltered, the helix‐sense inversion causes discontinuous changes in the molecular arrangement and, by extension, the crystalline dimension. In this study, another transition was detected at a higher temperature from the left‐handed α‐helix to the π‐helix, the molecular chirality being unaffected.

中文翻译：

通过同步加速器 X 射线衍射直接测定参与聚 (β-苯基丙基 l-天冬氨酸) 螺旋方向反转的螺旋结构

通过同步加速器广角 X 射线衍射和小角 X 射线散射研究了固态聚（β-苯丙基l-天冬氨酸）（3PLA）的螺旋方向反转。转变前后特征螺距的直接测定表明，在加热和冷却循环期间，转变在具有相反螺旋方向的两个 α 螺旋之间可逆地发生。虽然六边形堆积保持不变，但螺旋感反转会导致分子排列的不连续变化，进而导致晶体尺寸的不连续变化。在这项研究中，在更高的温度下检测到从左手α-螺旋到 π-螺旋的另一个转变，分子手性不受影响。

更新日期：2021-04-28

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