Rheumatoid arthritis (RA) is of foremost concern among long-term autoimmune disorders, as it leads to inflammation, exudates, chondral degeneration, and painful joints. Because RA severity often fluctuates over time, a local drug delivery method that titrates release of therapeutics to arthritis bioactivity should represent a promising paradigm of RA therapy. Given the local nature of RA chronic illnesses, polysaccharide-drug delivering systems have the promise to augment therapeutic outcomes by offering controlled release of bioactive materials, diminishing the required frequency of administration, and preserving therapeutic levels in affected pathological regions. Herein, an intra-articular photothermal-laden injectable methylcellulose (MC) polymeric hydrogel carrier incorporating strontium ranelate (SrR) and sodium chloride was investigated to resolve these issues. Physicochemical and cellular characteristics of the MC carrier system were thoroughly evaluated. The slow release of SrR, enhancement of the material mechanical strength, and the potential of the non-invasive near-infrared photothermal gel to improve blood circulation and suppress inflammation in a mini-surgical model of RA were examined. Biocompatibility and suppression of intracellular ROS-induced inflammation were observed. This multifunctional photothermal MC hydrogel carrier is anticipated to be an alternative approach for future orthopedic disease treatment.

类风湿关节炎（RA）是长期自身免疫疾病中最重要的问题，因为它会导致炎症，渗出液，软骨变性和关节疼痛。由于RA的严重性通常会随着时间而波动，因此采用局部药物递送方法来滴定治疗剂对关节炎生物活性的释放，应该代表一种有前途的RA治疗范例。考虑到RA慢性病的局部性质，多糖药物输送系统有望通过提供生物活性物质的控释，减少所需的给药频率以及在受影响的病理区域内保持治疗水平来增强治疗效果。在此处，为了解决这些问题，研究了一种关节腔内光热负载可注射的甲基纤维素（MC）聚合物水凝胶载体，该载体掺入了雷奈酸锶（SrR）和氯化钠。彻底评估了MC载体系统的理化和细胞特性。在RA的微型手术模型中，研究了SrR的缓慢释放，材料机械强度的增强以及非侵入性近红外光热凝胶改善血液循环和抑制炎症的潜力。观察到了生物相容性和细胞内ROS诱导的炎症的抑制。这种多功能的光热MC水凝胶载体有望成为未来骨科疾病治疗的替代方法。彻底评估了MC载体系统的理化和细胞特性。在RA的微型手术模型中，研究了SrR的缓慢释放，材料机械强度的增强以及非侵入性近红外光热凝胶改善血液循环和抑制炎症的潜力。观察到了生物相容性和细胞内ROS诱导炎症的抑制。这种多功能的光热MC水凝胶载体有望成为未来骨科疾病治疗的替代方法。彻底评估了MC载体系统的理化和细胞特性。在RA的微型手术模型中，研究了SrR的缓慢释放，材料机械强度的增强以及非侵入性近红外光热凝胶改善血液循环和抑制炎症的潜力。观察到了生物相容性和细胞内ROS诱导的炎症的抑制。这种多功能的光热MC水凝胶载体有望成为未来骨科疾病治疗的替代方法。观察到了生物相容性和细胞内ROS诱导的炎症的抑制。这种多功能的光热MC水凝胶载体有望成为未来骨科疾病治疗的替代方法。观察到了生物相容性和细胞内ROS诱导的炎症的抑制。这种多功能的光热MC水凝胶载体有望成为未来骨科疾病治疗的替代方法。