Adolescence is known for its high level of risk-taking, and neurobiological alterations during this period may predispose to psychoactive drug initiation and progression into more severe use patterns. Stress is a risk factor for drug consumption, and post-weaning social isolation increases drug self-administration in rodents. This review aimed to provide an overview of the effects of adolescent social isolation on cocaine, amphetamine and nicotine use-related behaviours, highlighting the specific period when animals were submitted to stress and these drugs. We wondered if there was a specific period during adolescence that isolation stress would increase drug use vulnerability. A total of 323 publications from the Scopus, Web of Science and PubMed (Medline) electronic databases were identified using the words “social isolation” and “adolescence” and “drug” or “cocaine” or “amphetamine” or “nicotine”, resulting in 24 articles after analyses criteria following the PRISMA statement. The main points raised were social isolation during adolescence increased cocaine self-administration, amphetamine and nicotine locomotor activity. We did not observe a pattern of a specific moment during the adolescent period that could lead to an increased vulnerability to drug use. The precise conditions under which adolescent social stress alters drug use parameters are complex and likely depend on several factors.

青春期以冒险精神高昂而著称，在此期间神经生物学的改变可能会诱发精神活性药物的引发和发展为更严重的使用方式。压力是吸毒的危险因素，断奶后的社会隔离增加了啮齿类动物的药物自我管理。这篇综述旨在概述青少年社会隔离对可卡因，苯丙胺和尼古丁使用相关行为的影响，强调了动物遭受压力和这些药物的特定时期。我们想知道青春期是否有特定时期的孤立压力会增加药物使用的脆弱性。Scopus共有323种出版物，通过“社会隔离”和“青春期”，“药物”或“可卡因”或“安非他命”或“烟碱”一词来识别Web of Science和PubMed（Medline）电子数据库，根据PRISMA分析标准后得出24篇文章陈述。提出的要点是青春期的社会隔离，可卡因自我管理，苯丙胺和尼古丁运动能力的增加。我们没有观察到青春期某个特定时刻的模式，该模式可能导致吸毒的脆弱性增加。青少年社会压力改变药物使用参数的确切条件是复杂的，可能取决于几个因素。提出的要点是青春期的社会隔离，可卡因自我管理，苯丙胺和尼古丁运动能力的增加。我们没有观察到青春期某个特定时刻的模式，该模式可能导致吸毒的脆弱性增加。青少年社会压力改变药物使用参数的确切条件很复杂，可能取决于几个因素。提出的要点是青春期的社会隔离，可卡因自我管理，苯丙胺和尼古丁运动能力的增加。我们没有观察到青春期某个特定时刻的模式，该模式可能导致吸毒的脆弱性增加。青少年社会压力改变药物使用参数的确切条件很复杂，可能取决于几个因素。