Candida species are opportunistic fungi that can cause mucosal or invasive infections. Especially in biofilm-related infections, resistance is very high to anifungals; therefore more effective treatment strategies are needed. Farnesol(3,7,11-trimethyl-2,6,10-dodecatriene-1-ol) is the quorum sensing (QS) signal molecule and can interact with Candida species both as a QS molecule and as an exogenous agent. The aim of this study was to investigate the effects of farnesol on both the planktonic and biofilm forms of Candida species by colorimetric, microbiological, and electron microscopic methods. Obtained results demonstrated the inhibitory effect of farnesol on the planktonic and biofilm forms of Candida. Farnesol showed a biofilm-enhancing effect at lower concentrations. TEM findings showed the membrane and wall damage, vacuolization, or granulation in cells. SEM images confirmed biofilm reduction in pre-/post-biofilm applications as a result of farnesol treatment. In conclusion, farnesol can be used as an alternative agent to reduce the Candida biofilms, with future studies.

念珠菌属是可引起粘膜或侵袭性感染的机会性真菌。特别是在生物膜相关感染中，对真菌的耐药性非常高；因此需要更有效的治疗策略。Farnesol(3,7,11-trimethyl-2,6,10-dodecatriene-1-ol) 是群体感应 (QS) 信号分子，可以作为 QS 分子和外源性物质与念珠菌物种相互作用。本研究的目的是通过比色法、微生物学和电子显微镜方法研究法尼醇对念珠菌属浮游生物和生物膜形式的影响。获得的结果证明了法尼醇对念珠菌的浮游和生物膜形式的抑制作用. Farnesol 在较低浓度下表现出增强生物膜的作用。TEM 结果显示细胞膜和壁受损、空泡化或颗粒化。SEM 图像证实了法尼醇处理导致生物膜前/后生物膜应用减少。总之，在未来的研究中，法尼醇可用作减少念珠菌生物膜的替代药物。