A variety of multidrug-resistant bacteria is blamed for severe infections worldwide. The emergence of antimicrobial resistance constitutes a serious problem for healthcare systems around the world. Here we review techniques for the prevention and constraint of antimicrobial resistance, the risk factors, and the ways by which antimicrobial resistance spreads. We discuss strategies for containment of widespread infections caused by antibacterial drug-resistant bacteria, including internationally recognized guidelines of antibiotic stewardship, educational programs, and behavioral changes. Recent discoveries of novel therapeutic drugs that can be used against antimicrobial resistance are very promising. For instance, antisense oligonucleotides are novel drugs that can be used successfully against resistant bacteria. This technology has many advantages in the development of antibacterial drugs.

世界各地的严重感染都归咎于多种耐多药细菌。抗菌素耐药性的出现对世界各地的医疗系统构成了严重的问题。在这里，我们回顾了预防和限制抗菌素耐药性的技术，危险因素以及抗菌素耐药性传播的方式。我们讨论了遏制由抗菌药物耐药细菌引起的广泛感染的策略，包括国际公认的抗生素管理准则，教育计划和行为改变。可以用于抗微生物耐药性的新型治疗药物的最新发现非常有希望。例如，反义寡核苷酸是可以成功用于抗药性细菌的新型药物。