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Recent advances in the chemistry of pyridazine — an important representative of six-membered nitrogen heterocycles
Russian Chemical Reviews ( IF 7.0 ) Pub Date : 2020-03-31 , DOI: 10.1070/rcr4922
Pavel G. Sergeev , Valentin G. Nenajdenko

The review is devoted to recent advances in the chemistry of pyridazine — a six-membered heterocycle containing two nitrogen atoms in adjacent positions. The practical significance of title compounds is demonstrated and published data of the last decade devoted to them are considered systematically. The modern synthetic approaches to pyridazine derivatives are described in detail, analyzed and classified according to the precursor molecules involved in ring closure. The chemical properties of pyridazines are considered, including both reactions of the diazine ring and reactions of various substituents attached to the ring. Particular attention is given to the application of some pyridazine derivatives as pharmaceuticals, optical materials and ligands for catalysis.

The bibliography includes 180 references.



中文翻译:

哒嗪化学的最新进展-六元氮杂环的重要代表

该综述致力于哒嗪化学的最新进展-哒嗪杂环是在相邻位置包含两个氮原子的六元杂环。证明了标题化合物的实际意义,并系统地考虑了近十年来专门针对它们的已发表数据。哒嗪衍生物的现代合成方法根据闭环所涉及的前体分子进行了详细描述,分析和分类。考虑哒嗪的化学性质,包括二嗪环的反应和与该环连接的各种取代基的反应。特别注意某些哒嗪衍生物作为药物,光学材料和催化配体的应用。

参考书目包括180篇参考文献。

更新日期:2020-03-31
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