Immobilising giant unilamellar vesicles with zirconium metal–organic framework anchors,Soft Matter

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Immobilising giant unilamellar vesicles with zirconium metal–organic framework anchors
Soft Matter ( IF 2.9 ) Pub Date : 2021-2-9 , DOI: 10.1039/d0sm02188a
Christopher S. Jennings _{1,

2,

3,

4} , Jeremy S. Rossman _{5,

6,

7,

8} , Braeden A. Hourihan _{1,

2,

3,

4} , Ross J. Marshall _{9,

10,

11,

12,

13} , Ross S. Forgan _{9,

10,

11,

12,

13} , Barry A. Blight _{1,

2,

3,

4}

Affiliation

Lipid bilayer vesicles have provided a window into the function and fundamental properties of cells. However, as is the case for most living and soft matter, vesicles do not remain still. This necessitates some microscopy experiments to include a preparatory immobilisation step. Here, we describe a straightforward method to immobilise giant unilamellar vesicles (GUVs) using zirconium-based metal–organic frameworks (MOFs) and demonstrate that GUVs bound in this way will stay in position on a timescale of minutes to hours.

中文翻译：

用锆金属-有机骨架锚钉固定巨大的单层囊泡

脂质双层囊泡提供了进入细胞功能和基本特性的窗口。但是，与大多数生物和软物质一样，囊泡不会保持静止。这需要进行一些显微镜实验，以包括预固定步骤。在这里，我们描述了一种使用基于锆的金属有机框架（MOF）固定单层大囊泡（GUV）的简单方法，并证明以这种方式结合的GUV将在数分钟至数小时的时间内保持原位。

更新日期：2021-02-18

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