当前位置: X-MOL 学术J. Nat. Prod. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Antibacterial p-Terphenyl with a Rare 2,2′-Bithiazole Substructure and Related Compounds Isolated from the Marine-Derived Actinomycete Nocardiopsis sp. HDN154086
Journal of Natural Products ( IF 3.3 ) Pub Date : 2021-02-18 , DOI: 10.1021/acs.jnatprod.0c01296
Yimin Chang 1 , Qian Che 1 , Li Xing 1 , Chuanteng Ma 1 , Yaxin Han 1 , Tianjiao Zhu 1 , Blaine A Pfeifer 2 , Jixing Peng 3 , Guojian Zhang 1, 4 , Dehai Li 1, 4
Affiliation  

Assisted by MS/MS-based molecular networking and X-ray diffraction analysis, five new p-terphenyl derivatives, namely, nocarterphenyls D–H (15), were obtained and characterized from the cultures of the marine sediment-derived actinomycete Nocardiopsis sp. HDN154086. The skeleton of nocarterphenyl D (1) was defined to possess a rare 2,2′-bithiazole scaffold, naturally occurring for the first time, and nocarterphenyls E–H (25) are p-terphenylquinones with unusual thioether linked fatty acid methyl ester substitutions. Compound 1 showed promising activity against multiple bacteria with MIC values ranging from 1.5 to 6.2 μM, and 2 exhibited notable antibacterial activity against MRSA which surpassed the positive control ciprofloxacin.

中文翻译:

具有稀有 2,2'-联噻唑亚结构的抗菌对三联苯和从海洋衍生放线菌 Nocardiopsis sp. 中分离的相关化合物。HDN154086

在基于 MS/MS 的分子网络和 X 射线衍射分析的辅助下,从海洋沉积物衍生的放线菌Nocardiopsis的培养物中获得并表征了五种新的三联苯衍生物,即 nocarterphenyls D–H ( 15 ) sp. HDN154086。nocarterphenyl D ( 1 )的骨架被定义为具有罕见的 2,2'-联噻唑支架,这是第一次天然存在,并且 nocarterphenyls E–H ( 25 ) 是三联苯醌,具有不寻常的硫醚连接的脂肪酸甲基酯取代。化合物1对多种细菌显示出良好的活性,MIC 值范围为 1.5 至 6.2 μM,2对 MRSA 表现出显着的抗菌活性,超过阳性对照环丙沙星。
更新日期:2021-04-23
down
wechat
bug