Antibacterial p-Terphenyl with a Rare 2,2′-Bithiazole Substructure and Related Compounds Isolated from the Marine-Derived Actinomycete Nocardiopsis sp. HDN154086,Journal of Natural Products

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Antibacterial p-Terphenyl with a Rare 2,2′-Bithiazole Substructure and Related Compounds Isolated from the Marine-Derived Actinomycete Nocardiopsis sp. HDN154086
Journal of Natural Products ( IF 3.3 ) Pub Date : 2021-02-18 , DOI: 10.1021/acs.jnatprod.0c01296
Yimin Chang ₁ , Qian Che ₁ , Li Xing ₁ , Chuanteng Ma ₁ , Yaxin Han ₁ , Tianjiao Zhu ₁ , Blaine A Pfeifer ₂ , Jixing Peng ₃ , Guojian Zhang _{1,

4} , Dehai Li _{1,

4}

Affiliation

Assisted by MS/MS-based molecular networking and X-ray diffraction analysis, five new p-terphenyl derivatives, namely, nocarterphenyls D–H (1–5), were obtained and characterized from the cultures of the marine sediment-derived actinomycete Nocardiopsis sp. HDN154086. The skeleton of nocarterphenyl D (1) was defined to possess a rare 2,2′-bithiazole scaffold, naturally occurring for the first time, and nocarterphenyls E–H (2–5) are p-terphenylquinones with unusual thioether linked fatty acid methyl ester substitutions. Compound 1 showed promising activity against multiple bacteria with MIC values ranging from 1.5 to 6.2 μM, and 2 exhibited notable antibacterial activity against MRSA which surpassed the positive control ciprofloxacin.

中文翻译：

具有稀有 2,2'-联噻唑亚结构的抗菌对三联苯和从海洋衍生放线菌 Nocardiopsis sp. 中分离的相关化合物。HDN154086

在基于 MS/MS 的分子网络和 X 射线衍射分析的辅助下，从海洋沉积物衍生的放线菌Nocardiopsis的培养物中获得并表征了五种新的对三联苯衍生物，即 nocarterphenyls D–H ( 1 – 5 ) sp. HDN154086。nocarterphenyl D ( 1 )的骨架被定义为具有罕见的 2,2'-联噻唑支架，这是第一次天然存在，并且 nocarterphenyls E–H ( 2 – 5 ) 是对三联苯醌，具有不寻常的硫醚连接的脂肪酸甲基酯取代。化合物1对多种细菌显示出良好的活性，MIC 值范围为 1.5 至 6.2 μM，2对 MRSA 表现出显着的抗菌活性，超过阳性对照环丙沙星。

更新日期：2021-04-23

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