The sympathetic nervous system is important for the beat-by-beat regulation of arterial blood pressure and the control of blood flow to various organs. Microneurographic recordings of pulse-synchronous muscle sympathetic nerve activity (MSNA) are used by numerous laboratories worldwide. The transduction of hemodynamic and vascular responses elicited by spontaneous bursts of MSNA provides novel, mechanistic insight into sympathetic neural control of the circulation. While some of these laboratories have developed in-house software programs to analyze these sympathetic transduction responses, they are not openly available and most require higher level programming skills and/or costly platforms. In the present paper we present an open-source, Microsoft Excel-based analysis program designed to examine the pressor and/or vascular responses to spontaneous resting bursts of MSNA, including across longer, continuous MSNA burst sequences, as well as following heartbeats not associated with MSNA bursts. An Excel template with embedded formulas is provided. Detailed written and video recorded instructions are provided to help facilitate the user and promote its implementation amongst the research community. Open science activities such as the dissemination of analytical programs and instructions may assist other laboratories in their pursuit to answer novel and impactful research questions regarding sympathetic neural control strategies in human health and disease.

中文翻译：

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分析自发性交感神经血流动力学转导的开源程序

交感神经系统对于逐次调节动脉血压和控制流向各个器官的血流很重要。脉冲同步肌肉交感神经活动 (MSNA) 的显微神经影像记录被世界各地的许多实验室使用。MSNA 的自发爆发引起的血流动力学和血管反应的转导为循环的交感神经控制提供了新颖的机械洞察力。虽然其中一些实验室已经开发了内部软件程序来分析这些交感神经转导反应，但它们不是公开可用的，并且大多数需要更高水平的编程技能和/或昂贵的平台。在本文中，我们提出了一个开源的，基于 Microsoft Excel 的分析程序旨在检查对 MSNA 的自发静息爆发的升压和/或血管反应，包括跨越更长、连续的 MSNA 爆发序列，以及与 MSNA 爆发无关的跟随心跳。提供了一个带有嵌入公式的 Excel 模板。提供了详细的书面和视频记录说明，以帮助用户方便并促进其在研究社区中的实施。开放科学活动，如分析程序和指令的传播，可以帮助其他实验室回答有关人类健康和疾病中交感神经控制策略的新颖和有影响力的研究问题。以及跟随与 MSNA 爆发无关的心跳。提供了一个带有嵌入公式的 Excel 模板。提供了详细的书面和视频记录说明，以帮助用户方便并促进其在研究社区中的实施。开放科学活动，如分析程序和指令的传播，可以帮助其他实验室回答有关人类健康和疾病中交感神经控制策略的新颖和有影响力的研究问题。以及跟随与 MSNA 爆发无关的心跳。提供了一个带有嵌入公式的 Excel 模板。提供了详细的书面和视频记录说明，以帮助用户方便并促进其在研究社区中的实施。开放科学活动，如分析程序和指令的传播，可以帮助其他实验室回答有关人类健康和疾病中交感神经控制策略的新颖和有影响力的研究问题。