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Application of a semi‐automatic, intensive follow‐up for improving efficacy and adherence of Helicobacter pylori eradication therapy: A randomized controlled trial
MicrobiologyOpen ( IF 3.9 ) Pub Date : 2021-02-17 , DOI: 10.1002/mbo3.1172 Yao Chen 1 , Hongxun Yuan 2 , Hui Ye 3 , Zongming Shi 3 , Xin Deng 3 , Xuezhi Zhang 1 , Xikang Hou 4
MicrobiologyOpen ( IF 3.9 ) Pub Date : 2021-02-17 , DOI: 10.1002/mbo3.1172 Yao Chen 1 , Hongxun Yuan 2 , Hui Ye 3 , Zongming Shi 3 , Xin Deng 3 , Xuezhi Zhang 1 , Xikang Hou 4
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A complete understanding and good adherence are crucial for successful Helicobacter pylori eradication. Proper frequency of reminders might be helpful to both doctors and patients to maintain adherence during treatment. The study was to evaluate the influence of an intensive follow‐up system based on a clinical database on H. pylori eradication therapy. A total of 196 eligible patients were equally and randomly divided into an intensive follow‐up group and a control group. Both groups were administered bismuth‐containing quadruple therapy for 14 days. Patients in the intensive follow‐up group were informed of pre‐treatment, including the duration and potential adverse events. Subsequently, they received telephone follow‐ups on days 3 and 14 and 3 days before the urea breath test (UBT). The time points were automatically reminded by a follow‐up system in the established clinical database. The control group was only informed of pre‐treatment information. UBT was performed 4 weeks after treatment in both groups to assess the presence of H. pylori. The eradication rate, patient compliance, and adverse events were calculated and compared. The H. pylori eradication rates of the intensive follow‐up and control groups were 94.7% (90/95, 95% CI: 90%–99%) and 92.9% (78/84, 95% CI: 87%–98%), respectively, by PP analysis (p = 0.601), and 91.8% (90/98, 95% CI: 86%–97%) and 81.6% (80/98, 95% CI: 74%–89%) by ITT analysis (p = 0.035). Adverse events occurred in 9 intensive follow‐up group patients and 12 in the control group. Adherence was 96.9% (95/98) in the intensive follow‐up group and 85.7% (84/98) in the control group. Semi‐automatic intensive follow‐up contributed to a higher eradication rate and adherence to H. pylori treatment.
中文翻译：
应用半自动强化随访提高幽门螺杆菌根除治疗的疗效和依从性：一项随机对照试验
完整的理解和良好的依从性对于成功根除幽门螺杆菌至关重要。适当的提醒频率可能有助于医生和患者在治疗期间保持依从性。该研究旨在评估基于临床数据库的强化随访系统对幽门螺杆菌的影响。幽门螺杆菌根除治疗。共有196名符合条件的患者被随机分为强化随访组和对照组。两组均接受含铋四联疗法，为期14天。强化随访组的患者被告知治疗前的情况，包括持续时间和潜在的不良事件。随后，他们在第 3 天、第 14 天以及尿素呼气测试 (UBT) 前 3 天接受了电话随访。已建立的临床数据库中的随访系统会自动提醒时间点。对照组仅被告知治疗前信息。两组治疗后 4 周均进行 UBT，以评估幽门螺杆菌的存在。幽门螺杆菌。计算并比较根除率、患者依从性和不良事件。 H .强化随访组和对照组的幽门螺杆菌根除率分别为 94.7% (90/95, 95% CI: 90%–99%) 和 92.9% (78/84, 95% CI: 87%–98%) ，通过 PP 分析 ( p = 0.601)，通过 ITT 分析 (p = 0.601)，91.8% (90/98, 95% CI: 86%–97%) 和 81.6% (80/98, 95% CI: 74%–89%) p = 0.035）。强化随访组有 9 名患者发生不良事件，对照组有 12 名患者发生不良事件。强化随访组的依从率为 96.9% (95/98)，对照组的依从率为 85.7% (84/98)。 半自动强化随访有助于提高H根除率和依从性。幽门螺杆菌治疗。
更新日期：2021-02-18
中文翻译：
应用半自动强化随访提高幽门螺杆菌根除治疗的疗效和依从性：一项随机对照试验
完整的理解和良好的依从性对于成功根除幽门螺杆菌至关重要。适当的提醒频率可能有助于医生和患者在治疗期间保持依从性。该研究旨在评估基于临床数据库的强化随访系统对幽门螺杆菌的影响。幽门螺杆菌根除治疗。共有196名符合条件的患者被随机分为强化随访组和对照组。两组均接受含铋四联疗法，为期14天。强化随访组的患者被告知治疗前的情况，包括持续时间和潜在的不良事件。随后，他们在第 3 天、第 14 天以及尿素呼气测试 (UBT) 前 3 天接受了电话随访。已建立的临床数据库中的随访系统会自动提醒时间点。对照组仅被告知治疗前信息。两组治疗后 4 周均进行 UBT，以评估幽门螺杆菌的存在。幽门螺杆菌。计算并比较根除率、患者依从性和不良事件。 H .强化随访组和对照组的幽门螺杆菌根除率分别为 94.7% (90/95, 95% CI: 90%–99%) 和 92.9% (78/84, 95% CI: 87%–98%) ，通过 PP 分析 ( p = 0.601)，通过 ITT 分析 (p = 0.601)，91.8% (90/98, 95% CI: 86%–97%) 和 81.6% (80/98, 95% CI: 74%–89%) p = 0.035）。强化随访组有 9 名患者发生不良事件，对照组有 12 名患者发生不良事件。强化随访组的依从率为 96.9% (95/98)，对照组的依从率为 85.7% (84/98)。 半自动强化随访有助于提高H根除率和依从性。幽门螺杆菌治疗。
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