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Platelet‐Mimicking Therapeutic System for Noninvasive Mitigation of the Progression of Atherosclerotic Plaques
Advanced Science ( IF 14.3 ) Pub Date : 2021-02-18 , DOI: 10.1002/advs.202004128 Yi Ma 1 , Yuxuan Ma 1 , Mengqiu Gao 1 , Zhihao Han 1 , Wen Jiang 1 , Yueqing Gu 1 , Yi Liu 1
Advanced Science ( IF 14.3 ) Pub Date : 2021-02-18 , DOI: 10.1002/advs.202004128 Yi Ma 1 , Yuxuan Ma 1 , Mengqiu Gao 1 , Zhihao Han 1 , Wen Jiang 1 , Yueqing Gu 1 , Yi Liu 1
Affiliation
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Atherosclerotic plaque is the primary cause of cardiovascular disorders and remains a therapeutic hurdle for the early intervention of atherosclerosis. Traditional clinical strategies are often limited by surgery‐related complications or unsatisfactory effects of long‐term drug administration. Inspired by the plaque‐binding ability of platelets, a biomimic photodynamic therapeutic system is designed to mitigate the progression of atherosclerotic plaques. This system is composed of photosensitizer‐loaded upconversion nanoparticle cores entrapped in the platelet membrane. The platelet membrane coating facilitates specific targeting of the therapeutic system to macrophage‐derived foam cells, the hallmark, and main component of early stage atherosclerotic plaques, which is firmly confirmed by in vivo fluorescent and single‐photon emission computed tomography/computed tomography (SPECT/CT) radionuclide imaging. Importantly, in vivo phototherapy guided by SPECT/CT imaging alleviates plaque progression. Further immunofluorescence analysis reveals foam cell apoptosis and ameliorated inflammation. This biomimic system, which combines plaque‐binding with radionuclide imaging guidance, is a novel, noninvasive, and potent strategy to mitigate the progression of atherosclerotic plaque.
中文翻译：
用于无创缓解动脉粥样硬化斑块进展的模拟血小板治疗系统
动脉粥样硬化斑块是心血管疾病的主要原因，并且仍然是动脉粥样硬化早期干预的治疗障碍。传统的临床策略往往受到手术相关并发症或长期用药效果不理想的限制。受血小板斑块结合能力的启发，仿生光动力治疗系统旨在减缓动脉粥样硬化斑块的进展。该系统由包埋在血小板膜中的负载光敏剂的上转换纳米颗粒核心组成。血小板膜涂层有利于治疗系统特异性靶向巨噬细胞衍生的泡沫细胞，这是早期动脉粥样硬化斑块的标志和主要成分，体内荧光和单光子发射计算机断层扫描/计算机断层扫描（SPECT）充分证实了这一点/CT）放射性核素成像。重要的是，SPECT/CT 成像引导的体内光疗可减轻斑块进展。进一步的免疫荧光分析揭示了泡沫细胞凋亡和炎症改善。这种仿生系统将斑块结合与放射性核素成像引导相结合，是一种新颖、无创且有效的策略，可以减轻动脉粥样硬化斑块的进展。
更新日期：2021-04-22
中文翻译：
用于无创缓解动脉粥样硬化斑块进展的模拟血小板治疗系统
动脉粥样硬化斑块是心血管疾病的主要原因，并且仍然是动脉粥样硬化早期干预的治疗障碍。传统的临床策略往往受到手术相关并发症或长期用药效果不理想的限制。受血小板斑块结合能力的启发，仿生光动力治疗系统旨在减缓动脉粥样硬化斑块的进展。该系统由包埋在血小板膜中的负载光敏剂的上转换纳米颗粒核心组成。血小板膜涂层有利于治疗系统特异性靶向巨噬细胞衍生的泡沫细胞，这是早期动脉粥样硬化斑块的标志和主要成分，体内荧光和单光子发射计算机断层扫描/计算机断层扫描（SPECT）充分证实了这一点/CT）放射性核素成像。重要的是，SPECT/CT 成像引导的体内光疗可减轻斑块进展。进一步的免疫荧光分析揭示了泡沫细胞凋亡和炎症改善。这种仿生系统将斑块结合与放射性核素成像引导相结合，是一种新颖、无创且有效的策略，可以减轻动脉粥样硬化斑块的进展。
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