Obesity is a condition of chronic tissue inflammation and oxidative stress that poses as a risk factor for male infertility. Moringa oleifera oil extract is known to have cholesterol-lowering properties and a potential to treat obesity, while lycopene is a potent antioxidant. We hypothesize that Moringa or lycopene may improve male fertility markers in an animal model of diet-induced obesity. Male Albino rats (n = 60) were randomized to receive regular chow (RC) or high-fat diet (HFD) for 12 weeks (n = 30 each). Animals in each arm were further randomized to receive gavage treatment with corn oil (vehicle), lycopene (10 mg/kg), or Moringa (400 mg/kg) for four weeks starting on week 9 (n = 10 each). Animals were sacrificed at 12 weeks, and blood was collected to assess lipid profile, serum testosterone, and gonadotropin levels. The testes and epididymides were removed for sperm analysis, oxidative stress and inflammatory markers, and histopathological assessment. In comparison to their RC littermates, animals on HFD showed an increase in body weights, serum lipids, testosterone and gonadotrophin levels, testicular oxidative stress and inflammatory markers, as well as sperm abnormalities and disrupted testicular histology. Moringa or lycopene reduced body weight, improved oxidative stress, and male fertility markers in HFD-fed animals with lycopene exhibiting better anti-antioxidant and anti-lipidemic effects. Lycopene is superior to Moringa in improving male fertility parameters, possibly by attenuating oxidative stress.

肥胖是慢性组织炎症和氧化应激的病状，是 男性不育的危险因素。辣木油提取物已知具有降低胆固醇的作用 特性和治疗肥胖症的潜力，而番茄红素是有效的抗氧化剂。我们假设辣木或番茄红素可以改善饮食引起的肥胖症动物模型中的男性生育指标。将雄性白化病大鼠（n = 60）随机接受常规食物（RC）或高脂饮食（HFD），持续12周（每组n = 30）。从第9周开始，每组动物进一步随机分配接受玉米油（媒介物），番茄红素（10 mg / kg）或辣木（400 mg / kg）的管饲治疗（每组n = 10），持续四周。在第12周处死动物，并收集血液以评估脂质分布，血清睾丸激素和促性腺激素水平。除去睾丸和附睾，进行精子分析，氧化应激和炎症标记以及组织病理学评估。与他们的RC同窝仔相比，使用HFD的动物体重，血清脂质，睾丸激素和促性腺激素水平，睾丸氧化应激和炎性标志物以及精子异常和睾丸组织学异常均增加。辣木或番茄红素减轻了体重，改善了氧化应激，并在高密度脂蛋白喂养的动物中添加番茄红素表现出更好的抗氧化和抗血脂作用。番茄红素在改善雄性育性参数方面可能优于辣木，可能是通过减轻氧化应激来实现的。和HFD饲喂番茄红素的动物的雄性育性标记物表现出更好的抗氧化和抗血脂作用。番茄红素在改善雄性育性参数方面可能优于辣木，可能是通过减轻氧化应激来实现的。和HFD饲喂番茄红素的动物的雄性育性标记物表现出更好的抗氧化和抗血脂作用。番茄红素在改善雄性育性参数方面可能优于辣木，可能是通过减轻氧化应激来实现的。