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Antioxidant effect of ethanolic onion (Allium cepa) husk extract in ageing rats
Saudi Journal of Biological Sciences ( IF 4.4 ) Pub Date : 2021-02-17 , DOI: 10.1016/j.sjbs.2021.02.020
Irina Chernukha , Liliya Fedulova , Ekaterina Vasilevskaya , Andrei Kulikovskii , Nadezhda Kupaev , Elena Kotenkova

The role of natural antioxidants in preventing of age-relating diseases is evident. The vegetable industry generates a large amount of waste, which is a good source of antioxidants.

The aim of the study was the investigation of the antioxidant effect of long-term consumption of ethanolic yellow onion husk extract in ageing laboratory rodents.

Twenty male Wistar albino rats were divided randomly into two groups (n = 10): a control group and an experimental group that received ethanolic yellow onion husk extract (2 mL/rat diluted with distilled water; activity of 4.44 µmol-equiv. quercetin) for 188 days. Oxygen radical absorbance capacity and ferric reducing antioxidant power assays were used to determine the total antioxidant capacity of the extract, which amounted to 941.4 ± 32.7 µmol equiv. Trolox/g raw material and 167.4 ± 16.4 µmol-equiv. quercetin/g raw material, respectively. Oral intake of the onion husk extract affected the indicators of the antioxidant system of the liver and the brain but not of the blood and plasma, mainly due to elevations in the activity of catalase and superoxide dismutase in the liver by 44.4% and 79.1%, respectively, and in the brain by three-fold and 79.1%, respectively.

The availability, cheapness and high antioxidant potential of onion waste qualifies it a good source of functional ingredients and bioactive substances applicable in the food and pharmaceutical industries.



中文翻译:

乙醇洋葱(的抗氧化效果洋葱衰老大鼠)果壳提取物

天然抗氧化剂在预防与年龄有关的疾病中的作用是显而易见的。蔬菜行业会产生大量废物,这是抗氧化剂的良好来源。

该研究的目的是研究长期食用乙醇黄洋葱皮提取物在老化的实验室啮齿动物中的抗氧化作用。

将20只雄性Wistar白化病大鼠随机分为两组(n = 10):对照组和实验组,接受乙醇黄洋葱皮提取物(每毫升大鼠2mL,用蒸馏水稀释;活度为4.44 µmol当量的槲皮素)持续188天。氧自由基吸收能力和铁还原抗氧化剂能力测定法用于确定提取物的总抗氧化剂能力,总计为941.4±32.7 µmol当量。Trolox / g原料和167.4±16.4 µmol当量。槲皮素/克原料。口服洋葱皮提取物会影响肝脏和大脑的抗氧化系统的指标,但不会影响血液和血浆的指标,这主要是由于肝脏中过氧化氢酶和超氧化物歧化酶的活性分别升高了44.4%和79.1%,分别是大脑的三倍和79。

洋葱废物的可获得性,便宜性和高抗氧化潜力使其成为食品和制药行业中适用的功能性成分和生物活性物质的良好来源。

更新日期:2021-02-17
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