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Hematobiochemical and histopathological alterations of kidney and testis due to exposure of 4G cell phone radiation in mice
Saudi Journal of Biological Sciences Pub Date : 2021-02-17 , DOI: 10.1016/j.sjbs.2021.02.028
Imam Hasan , Tanjina Amin , Md. Rafiqul Alam , Mohammad Rafiqul Islam

The radiofrequency electromagnetic radiation emitted by smart phones on biological systems has wide media coverage and public concern in recent years. The aim of this study was to explore the effects of fourth-generation cell phone radiation exposure on hematological (Total leukocyte count, Total erythrocyte count, and hemoglobin %), biochemical (Serum creatinine) parameters, and histopathological changes in the kidney and testis of Swiss albino mice. A total of 30 male Swiss albino mice weighing 45–65 g was randomly divided into three groups (n = 10). The first group A was the control group, the second group B, was exposed to 40 minutes of mobile phone radiation daily, the third group C was exposed to 60 minutes of radiation daily from two 2400 Megahertz fourth-generation connected mobile phones for 60 days, respectively. The electromagnetic radiation frequency radiometer measured the frequency of electromagnetic radiation emitted from cell phones. The specific absorption rate was calculated as 0.087 W/kg. The control group was kept under similar conditions, but the electromagnetic field was not given for the same period. All the mice were sacrificed at the end of the experiment. The blood samples were collected for hematobiochemical study, and then kidney and testis tissues were collected for histopathological study. Results of the study showed that the body weight and total erythrocyte count values were significantly (p < 0.05) decreased while total leukocyte count, hemoglobin %, and serum creatinine values were significantly (p < 0.05) increased in both the radiation exposure groups relative to the control group. Histopathological observation showed the kidney of 60 minutes exposed mice interstitial inflammation that causes marked mononuclear cellular infiltration compared to the 40 minutes and control mice. Compared to control mice, histopathological examinations of testicular tissue from the exposed mice, showed irregular in shapes and non-uniform sizes and fewer spermatogenic cells layer that leads to the larger lumen in the seminiferous tubules. It is concluded that fourth-generation cell phone radiation exposure may affect blood hemostasis and inflammation of mice's kidney and testis tissue. Based on these studies, it is important to increase public consciousness of potential adverse effects of mobile phone radiofrequency electromagnetic radiation exposure.



中文翻译:

小鼠暴露于4G手机辐射导致肾脏和睾丸的血液生化和组织病理学改变

近年来,智能手机在生物系统上发出的射频电磁辐射已得到广泛的媒体报道和公众关注。这项研究的目的是探讨第四代手机辐射暴露对血液学(总白细胞计数,总红细胞计数和血红蛋白%),生化(血清肌酐)参数以及肾脏和睾丸组织病理学变化的影响。瑞士白化病小鼠。总共30头体重45-65 g的瑞士白化病雄性小鼠随机分为三组(n = 10)。第一组A为对照组,第二组B每天暴露于40分钟的手机辐射中,第三组C每天暴露于来自两台2400 MHz第四代连接手机的60分钟辐射中, 分别。电磁辐射频率辐射仪测量手机发出的电磁辐射的频率。比吸收率经计算为0.087W / kg。对照组被保持在相似的条件下,但是在同一时期没有给予电磁场。实验结束时处死所有小鼠。收集血样进行血液生化研究,然后收集肾脏和睾丸组织进行组织病理学研究。研究结果表明,与放射线照射组相比,相对于放射线照射组,体重和总红细胞计数值显着降低(p <0.05),而总白细胞计数,血红蛋白%和血清肌酐值显着升高(p <0.05)。对照组。组织病理学观察显示,与40分钟和对照组的小鼠相比,暴露60分钟的小鼠的肾间质炎症引起明显的单核细胞浸润。与对照小鼠相比,来自暴露小鼠的睾丸组织的组织病理学检查显示形状不规则且大小不均匀,生精细胞层较少,导致生精小管腔变大。结论是第四代手机辐射暴露可能会影响小鼠肾脏和睾丸组织的止血和炎症。基于这些研究,重要的是提高公众对手机射频电磁辐射暴露潜在不利影响的认识。

更新日期:2021-02-17
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