To investigate the correlation between serum renin-angiotensin system (RAS) level and Symptoms of anxiety and depression in Parkinson disease patients (PD). A number of 90 PD patients (47 males and 43 females) were collected on an empty stomach 12 h after stopping taking anti-PD medicines. ELISA has been found in Serum RAS ((Ang) I, Ang II, Ang (1–7), Angiotensin converting enzyme (ACE), ACE2). Depression scale (HAMD) and Anxiety scale (HAMA) in Hamilton are used for the assessment of signs of depression and anxiety. The 90 patients were diagnosed with moderate depression (HAMD score 8 ~ 19); in 32 of those (35.56 percent), and 12 (13.33%) were diagnosed as moderate and severe depression (HAMD score ≥ 20). 20 cases (22.22%) were diagnosed as possible anxiety disorder (HAMA score 7 ~ 13) and 16 cases (17.78%) as definite anxiety disorder (HAMA score ≥ 14). The association of serum Ang I, Ang II and Ang (1–7) with HAMD (r= − 0.820, P < 0.001; r = −0.846, P < 0.001) showed negative linkage with HAMD (r = −0.887, P < 0.003; P < 0.001; Negative correlation of the settings with HAMA (r = −0.850, P < 0.001; r = −0.887, P < 0.001; r = 0.003; r = 0.001, P < 0.001, Fig. 2, Fig. 3); The HAMD score and the HAMA score (all P > 0.05) were not associated to the serum ACE and ACE2. The serum Ang I, Ang II, and Ang (1–7) were found to be adversely associated with HAMD score (r = 0.826, P < 0,001; r = −0.818, p> >0,001; r = −0.876, P < 0,001; P = 0,001) P < 0,001; And have been negatively correlated (r = 0.870, Fig. 1, Fig. 2, Fig. 3) with AMA-scores (r = −0.876, P < 0.001, Table 1, Fig. 3), R = −0.862, P > 0.001; The HAMD score and the HAMA score (all P > 0.05) were not correlated to the serum ACE and ACE2. Finally, in PD patients, non-engine signs, including depression and anxiety, are normal. Thus, Serum levels Ang I, Ang II and Ang (1–7) were substantially decreased in female and male patients and associated with symptoms of depression and anxiety, ACE and ACE2 levels have not been attributed to signs of depression and anxiety. Serum Ang I, Ang II, and Ang (1–7) are important markers of depression and anxiety prevention and diagnosis in patients with DP.

目的探讨帕金森病患者（PD）的血清肾素-血管紧张素系统（RAS）水平与焦虑和抑郁症状之间的相关性。在停止服用抗PD药物12小时后，空腹收集了90例PD患者（47例男性和43例女性）。已在血清RAS（（Ang）I，Ang II，Ang（1-7），血管紧张素转化酶（ACE），ACE2）中发现了ELISA。汉密尔顿的抑郁量表（HAMD）和焦虑量表（HAMA）用于评估抑郁和焦虑的体征。90例患者被诊断为中度抑郁症（HAMD评分8〜19）；其中32例（35.56％）和12例（13.33％）被诊断为中度和重度抑郁（HAMD评分≥20）。20例（22.22％）被诊断为可能的焦虑症（HAMA评分7〜13）和16例（17。78％）为明确的焦虑症（HAMA评分≥14）。血清Ang I，Ang II和Ang（1-7）与HAMD的关联（r = − 0.820，P <0.001; r = −0.846，P <0.001）显示与HAMD负相关（r = −0.887，P < 0.003; P <0.001;设置与HAMA的负相关性（r = -0.850，P <0.001; r = -0.887，P <0.001; r = 0.003; r = 0.001，P <0.001，图2，图3）; HAMD评分和HAMA评分（均P> 0.05）与血清ACE和ACE2不相关，血清Ang I，Ang II和Ang（1–7）与HAMD评分呈负相关（r = 0.826，P <0,001; r = -0.818，p>> 0.001; r = -0.876，P <0,001; P = 0,001）P <0,001;并且已经负相关（r = 0.870，图1，图2，图3）和AMA得分（r = -0.876，P <0.001，表1，图3），R = -0.862，P> 0.001; HAMD评分和HAMA评分（均P> 0.05）与血清ACE和ACE2不相关。最后，在PD患者中，非发动机体征，包括抑郁症和焦虑症是正常的。因此，女性和男性患者的血清Ang I，Ang II和Ang（1-7）水平显着降低，并伴有抑郁和焦虑症状，ACE和ACE2水平并未归因于抑郁和焦虑迹象。血清Ang I，Ang II和Ang（1–7）是DP患者抑郁和焦虑症预防和诊断的重要标志。女性和男性患者的Ang II和Ang（1–7）显着降低，并伴有抑郁和焦虑症状，ACE和ACE2水平并未归因于抑郁和焦虑的迹象。血清Ang I，Ang II和Ang（1–7）是DP患者抑郁和焦虑预防和诊断的重要标志。女性和男性患者的Ang II和Ang（1–7）显着降低，并伴有抑郁和焦虑症状，ACE和ACE2水平并未归因于抑郁和焦虑的迹象。血清Ang I，Ang II和Ang（1–7）是DP患者抑郁和焦虑症预防和诊断的重要标志。