This study aims to develop an inner selective coordination nanofiltration hollow fiber (CNHF) membrane for the efficient removal of antibiotics from groundwater. In the first step, a modified substrate with the controlled modification degree is achieved by pressure-assisted alkali modification of polyimide hollow fiber substrate to provide the active points for the construction of the dense active layer. Then, the high-performance active layer is dynamically built on the modified substrate by the coordination between Fe³⁺ and phytic acid. Compared to static synthesis, the pure water permeability (PWP) of the membrane is improved from 4.1 to 8.5 Lm⁻²h⁻¹bar⁻¹ and Na₂SO₄ rejection enhanced from 68.3% to 97.0% by the dynamic synthesis with a cross-flow system. The newly developed membranes exhibit high rejection to several pharmaceuticals (>99%). This work may provide insightful guidelines for improving the fabrication procedures and scaling up the inner-selective CNHF membrane modules for water purification and other applications.

这项研究旨在开发一种内部选择性配位纳米过滤中空纤维（CNHF）膜，用于有效去除地下水中的抗生素。在第一步中，通过对聚酰亚胺中空纤维基材进行压力辅助碱改性以提供用于构造致密活性层的活性点，来获得具有受控改性度的改性基材。然后，通过Fe ³⁺和植酸之间的配位，在改性后的基材上动态构建高性能活性层。与静态合成相比，膜的纯水渗透率（PWP）从4.1提高到8.5 Lm ^-2 h ^-1 bar ^-1和Na ₂ SO ₄通过错流系统进行动态合成，抑制率从68.3％提高到97.0％。新开发的膜表现出对多种药物的高度排斥（> 99％）。这项工作可能会提供有见地的指导方针，以改善制造程序并扩大用于水净化和其他应用的内部选择性CNHF膜组件。