Moving while you’re stuck: a macroscopic demonstration of an active system inspired by binding-mediated transport in biology,Soft Matter

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Moving while you’re stuck: a macroscopic demonstration of an active system inspired by binding-mediated transport in biology
Soft Matter ( IF 2.9 ) Pub Date : 2021-1-25 , DOI: 10.1039/d0sm01808b
Kanghyeon Koo ₁ , Shankar Lalitha Sridhar ₂ , Noel Clark ₃ , Franck Vernerey ₄ , Loren Hough ₅

Affiliation

Diffusive motion is typically constrained when particles bind to the medium through which they move. However, when binding is transient and the medium is made of flexible filaments, each association or dissociation event produces a stochastic force that can overcome the medium stickiness and enable motion. This mechanism is amply used by biological systems where the act of balancing binding and displacement robustly achieves key functionalities, including bacterial locomotion or selective active filtering in cells. Here we demonstrate the feasibility of making a dynamic system with macroscopic features, in which analogous binding-mediated motion can be actively driven, precisely tuned, and conveniently studied. We find an optimal binding affinity and number of binding sites for diffusive motion, and an inverse relationship between viscosity and diffusivity.

中文翻译：

受困时移动：受生物学中结合介导的运输启发的主动系统的宏观演示

当粒子与它们移动的介质结合时，扩散运动通常会受到限制。然而，当结合是短暂的并且介质由柔性细丝制成时，每次缔合或解离事件都会产生可以克服介质粘性并实现运动的随机力。这种机制被生物系统广泛使用，其中平衡结合和位移的行为稳健地实现了关键功能，包括细菌运动或细胞中的选择性主动过滤。在这里，我们展示了制作具有宏观特征的动态系统的可行性，其中类似的结合介导的运动可以被主动驱动、精确调节并方便地研究。我们找到了扩散运动的最佳结合亲和力和结合位点数量，以及粘度和扩散率之间的反比关系。

更新日期：2021-02-17

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