Chronic neuropathic pain syndrome is associated with impaired quality of life and is poorly manageable. Alpha lipoic acid (ALA) is a powerful antioxidant and showed its effectiveness on diabetic neuropathy and other acute peripheral nerve injuries but it was not evaluated in the chronic neuropathic pain, chronic constriction injury (CCI) in rat model by using duloxetine (DLX) as standard. The main objective of the study was to expedite ALA effect on chronic peripheral neuropathy induced by CCI of sciatic nerve in rats. In this study, male Wister rats were randomly divided into six groups (n = 8) including, normal saline, sham operated, surgery control, DLX 30mg/kg treated, ALA treated 25mg/kg, and ALA+DLX. The CCI of sciatic nerve was conducted on all animals except normal saline group and studied for 21 days (i.e. 14 days treatment period & 7 days treatment free period) by using different behavioral, biochemical and, histopathology studies. ALA showed minor but significant decrease of thermal hyperalgesia, cold allodynia, malondialdehyde (MDA), total protein, lipid peroxidation, and nitric oxide levels and significant increase of motor coordination, glutathione level and decreased axonal degeneration significantly. These effects sustained even during treatment free period. ALA enhanced the effect of DLX when given in combination by showing sustained effect. In conclusion, ALA acted as potent antioxidant may be this activity is responsible for the potent neuroprotective effect. Hence, ALA attenuated the nueroinflammation mediated by chronic peripheral neuropathy. Further studies are warranted with ALA to develop as a clinically relevant therapeutic agent for the treatment of neuropathic pain.

中文翻译：

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硫辛酸减轻慢性坐骨神经损伤引起的神经痛

慢性神经性疼痛综合征与生活质量下降有关，且管理不善。硫辛酸（ALA）是一种强大的抗氧化剂，对糖尿病性神经病和其他急性周围神经损伤具有治疗作用，但尚未在大鼠模型中通过使用度洛西汀（DLX）作为慢性神经性疼痛，慢性压迫性损伤（CCI）进行评估。标准。这项研究的主要目的是加快ALA对大鼠坐骨神经CCI引起的慢性周围神经病变的作用。在这项研究中，雄性Wister大鼠随机分为6组（n = 8），包括生理盐水，假手术，手术控制，DLX 30mg / kg治疗，ALA治疗25mg / kg和ALA + DLX。除生理盐水组外，对所有动物进行坐骨神经CCI评估，并进行21天（即14天治疗期和 7天的无治疗期），通过使用不同的行为，生化和组织病理学研究。ALA表现为热痛觉过敏，冷异常性疼痛，丙二醛（MDA），总蛋白，脂质过氧化和一氧化氮水平轻微但显着降低，并且运动协调性，谷胱甘肽水平和轴突变性明显降低。这些效果甚至在无治疗期间也持续存在。当显示出持续作用时，ALA可增强DLX的作用。总之，ALA可能是有效的抗氧化剂，可能是这种活性负责有效的神经保护作用。因此，ALA减轻了由慢性周围神经病介导的神经炎症。