Some related reports indicate that the outer retinal membrane protein 1 (ROM1) functions importantly in the regulation of the biological process of tumor. Nevertheless, studies towards the role of ROM1 in lung cancer are few. Here, our data demonstrated that ROM1 displayed a relation with lung cancer tumorigenesis and development. In the Tumor Genome Atlas (TCGA) cohort, reduced ROM1 level was observed in lung cancer tissues, instead of normal tissues. After bioinformatics analysis, the data revealed that ROM1 level was associated with the tumor stage. Additional results indicated that highly expressed ROM1 exhibited a positive correlation with the overall survival rate, and ROM1 was probably a promising prognostic biomarker of lung cancer. Additionally, our results indicated that knocking out ROM1 could promote cell proliferation, migration, and invasion. Our data conclusively demonstrated that ROM1 modulated lung cancer tumorigenesis and development, as a prognosis and treatment biomarker.

中文翻译：

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外层视网膜膜蛋白 1 作为肿瘤抑制剂可以抑制肺癌进展

一些相关报道表明，外视网膜膜蛋白1（ROM1）在调节肿瘤的生物学过程中起重要作用。然而，关于 ROM1 在肺癌中的作用的研究很少。在这里，我们的数据表明 ROM1 显示出与肺癌肿瘤发生和发展的关系。在肿瘤基因组图谱 (TCGA) 队列中，在肺癌组织中观察到 ROM1 水平降低，而不是在正常组织中。经过生物信息学分析，数据显示 ROM1 水平与肿瘤分期有关。额外的结果表明，高表达的 ROM1 与总生存率呈正相关，ROM1 可能是肺癌有希望的预后生物标志物。此外，我们的结果表明，敲除 ROM1 可以促进细胞增殖、迁移、和入侵。我们的数据最终证明 ROM1 调节肺癌肿瘤的发生和发展，作为预后和治疗的生物标志物。