A Versatile Fluorescent Sensor Array for Platinum Anticancer Drug Detection in Biological Fluids,ACS Sensors

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A Versatile Fluorescent Sensor Array for Platinum Anticancer Drug Detection in Biological Fluids
ACS Sensors ( IF 8.2 ) Pub Date : 2021-02-17 , DOI: 10.1021/acssensors.0c02553
Linda Mitchell ₁ , Clara Shen ₁ , Hannah C. Timmins ₂ , Susanna B. Park ₂ , Elizabeth J. New _{1,

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Affiliation

Platinum complexes remain frontline anticancer therapies, even after 50 years of usage in clinical applications. However, there is still a lack of methodology to robustly detect and quantify these complexes in biological fluids. We report here a fluorescent sensor array comprising six sensors that demonstrates progress toward the detection of platinum levels in chemotherapy patients. Linear discriminant analysis was performed to examine each multidimensional data set, and the array was able to discriminate platinum from other biologically relevant metals and heavy metals and separately able to differentiate and identify platinum complexes with different coordination environments with 100% accuracy. Finally, the array showed sensitivity to various cisplatin and oxaliplatin concentrations in human plasma and was able to discriminate between a cohort of 27 cancer patients at different stages of platinum treatment. We envisage that our array system could lead to a better understanding of blood platinum concentrations of chemotherapy patients and could inform the modification of dosage regimes to minimize dose-limiting side effects.

中文翻译：

用于生物流体中铂类抗癌药物检测的多功能荧光传感器阵列。

即使在临床应用中使用了50年之后，铂络合物仍是一线抗癌疗法。然而，仍然缺乏可靠地检测和定量生物流体中这些复合物的方法。我们在这里报告了一个包含六个传感器的荧光传感器阵列，这些传感器演示了在化学疗法患者中检测铂水平的进展。进行线性判别分析以检查每个多维数据集，并且该阵列能够将铂与其他生物学上相关的金属和重金属区分开，并且能够分别以100％的准确度区分和鉴定具有不同配位环境的铂络合物。最后，该阵列显示出对人血浆中各种顺铂和奥沙利铂浓度的敏感性，并且能够区分27名处于铂治疗不同阶段的癌症患者。我们设想，我们的阵列系统可以更好地了解化疗患者的血铂浓度，并可以告知剂量方案的修改，以最大程度地减少剂量限制的副作用。

更新日期：2021-03-26

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