Purpose: To evaluate local control and functional and cosmetic outcomes of postoperative high-dose-rate interventional radiotherapy (HDR-IRT) in patients affected by conjunctival melanoma with orbit invasion. Methods: A retrospective study was conducted in 2 patients affected by conjunctival melanoma infiltrating the orbit, treated with surgical excision and HDR-IRT. The treatment procedures consisted of surgical excision of the orbital infiltrating nodule followed, 1 month after surgery, by adjuvant HDR-IRT. A target dose of 34 Gy was delivered in 10 twice-a-day fractions over 5 consecutive days. Data analysis included local tumor control and metastatic rate, acute and late toxicity, functional and aesthetic results. Results: In both patients, treatment was well tolerated, and there was no orbital recurrence at a median follow-up of 37–40 months. There was an excellent functional outcome, without no significant acute or late side effects. Conclusions: HDR-IRT could be considered a promising, feasible, successful, and well-tolerated option for selected patients affected by ocular tumors with orbital invasion.
Ocul Oncol Pathol

中文翻译：

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用于结膜黑色素瘤的高剂量率间质近距离放射治疗（介入放射治疗）

目的：评估眼眶侵犯的结膜黑色素瘤患者术后高剂量率介入放射治疗 (HDR-IRT) 的局部控制以及功能和美容效果。方法：对 2 例浸润眼眶的结膜黑色素瘤患者进行回顾性研究，接受手术切除和 HDR-IRT 治疗。治疗程序包括手术切除眼眶浸润结节，然后在手术后 1 个月进行辅助 HDR-IRT。34 Gy 的目标剂量在连续 5 天内分 10 次每天两次进行。数据分析包括局部肿瘤控制和转移率、急性和晚期毒性、功能和美学结果。结果：这两名患者的治疗耐受性良好，在中位随访 37-40 个月时没有眼眶复发。有极好的功能结果，没有明显的急性或晚期副作用。结论： HDR-IRT 可被认为是一种有前途、可行、成功且耐受性良好的选择，适用于受眼部肿瘤影响并伴有眼眶侵犯的特定患者。
眼肿瘤病理