Inactivation of SARS-CoV-2 in the Liquid Phase: Are Aqueous Hydrogen Peroxide and Sodium Percarbonate Efficient Decontamination Agents?,ACS Chemical Health & Safety

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Inactivation of SARS-CoV-2 in the Liquid Phase: Are Aqueous Hydrogen Peroxide and Sodium Percarbonate Efficient Decontamination Agents?
ACS Chemical Health & Safety ( IF 2.9 ) Pub Date : 2021-02-16 , DOI: 10.1021/acs.chas.0c00095
Davide Mileto ₁ , Alessandro Mancon ₁ , Federica Staurenghi ₁ , Alberto Rizzo ₁ , Stefano Econdi _{2,

3} , Maria Rita Gismondo ₁ , Matteo Guidotti ₂

Affiliation

A diluted 3% w/w hydrogen peroxide solution acidified to pH 2.5 by adding citric acid inactivated SARS-CoV-2 virus by more than 4 orders of magnitude in 5 min. After a contact time of 15 min, no viral replication was detected. Aqueous solutions of sodium percarbonate inactivated coronavirus by >3 log₁₀ diminution in 15 min. Conversely, H₂O₂ solutions with no additives displayed a scarce virucidal activity (1.1 log₁₀ diminution in 5 min), confirming that a pH-modifying ingredient is necessary to have a H₂O₂-based disinfectant active against the novel coronavirus.

中文翻译：

液相中 SARS-CoV-2 的灭活：过氧化氢水溶液和过碳酸钠是有效的净化剂吗？

通过添加柠檬酸将稀释的 3% w/w 过氧化氢溶液酸化至 pH 2.5，5 分钟内灭活 SARS-CoV-2 病毒超过 4 个数量级。接触时间15分钟后，没有检测到病毒复制。过碳酸钠水溶液在 15 分钟内使冠状病毒灭活>3 log ₁₀减少。相反，不含添加剂的H ₂ O _{2溶液显示出很少的杀病毒活性（5 分钟内减少 1.1 log}₁₀），这证实了 pH 调节成分对于具有针对新型冠状病毒的H ₂ O _{2消毒剂是必要的。}

更新日期：2021-02-16

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